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Recently, the journal Leukocyte Biology, a major journal of immunology, published a research paper online entitled "The epithelial cells of the nasal epithelial cell regulate the respiratory DC through TLR5/GM-CSF and enhance the IgA response" (Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of the dendritic cells and the IgA response).
The study found that the nasal mucosa epidural cells in the activation of the body on the bacterial whiplash, the pathogen-related molecular model of the immune response and its response characteristics have an important guiding role, in which the nasal mucosa epidural cell TLR5 path activation produced by GM-CSF is the key mediated molecule.
this finding not only reveals the activity mechanism of mucosal adjuncts of whiplash protein nasal immunity to enhance IgA response, but also is of great significance for further clarifying the unique mechanism of respiratory mucosa immune response.
mucosa is the main way for all kinds of air-borne bacteria and viral pathogens to invade the body.
induced respiratory mucosa-specific secretion type IgA antibody is the key to play the mucous membrane first immune defense line, can effectively improve the body's ability to prevent pathogen invasion.
previous studies have shown that respiratory DC can play a key role in the IgA response by participating in the IgA category conversion of naïve B cells through two ways: T-cell dependence and non-dependence.
, little attention has been paid to the role of mucosal epidural cells in immunomodal regulation, which interact with pathogens and pathogen-related molecular patterns first.
, a mucosa immunological group led by Yu Huimin, a researcher at the Wuhan Virus Research Institute of the Chinese Academy of Sciences, found in the study that whiplashin does not directly and effectively active the respiratory DC, and that direct stimulation of DC does not enhance the IgA response of naïve B cells.
that only by stimulating the epitome of the nasal mucosa can dc cells be further activated.
this suggests that whiplash protein is an indirect mode that transmits activation signals from mucous membrane epidural cells to DC, giving DC enhanced the ability of naïve B cell IgA to respond.
In the study, the subject group further used experimental techniques such as cytokine chips to find and prove that GM-CSF produced by the epidural cells of the nasal mucosa activated TLR5 path is the key cytokine that transmits the activation signal and regulates DC function.
this not only proves that mucosal epidural cells have immunomodal function, but also is the first time GM-CSF has been found to have the function of regulating DC to enhance IgA response.
the research paper was published online in frontline Science Highlight Article.
Maohua, assistant researcher of the mucous membrane immunology group of Wuhan Virus Institute, is the communication author of this research paper, and the subject group leader, Yu Huimin, is the co-author of the newsletter, and the doctoral student is the first author.
Mucosa Immunology Group has been focusing on "antiviral mechanisms and applications of IgA antibodies in mucous membrane immune defense" for many years, and has achieved a series of results in the development of recombinant whiplash mucosa adjuncts and the application of mucous membrane vaccines.
The study further clarified the cellular and molecular mechanisms of whiplash as a nasal mucosa adjunct to enhance IgA response, and obtained the National Infectious Diseases Major Special Project of the Ministry of Science and Technology (No.2012ZX10001-008), National Nature Science Fund Project (Nos.81302609, 81202312, 31300717, 81461130019), the Chinese Academy of Sciences "135 Program" cultivation project funding.
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