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    Home > The National Center for nanoscience has made a series of new progress in the field of "self-assembly in vivo" peptide drug delivery

    The National Center for nanoscience has made a series of new progress in the field of "self-assembly in vivo" peptide drug delivery

    • Last Update: 2019-11-10
    • Source: Internet
    • Author: User
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    Recently, Wang Hao and Zhao Yuliang of the National Center for nanoscience applied their new tumor specific cascade activated self retention system to in vivo self-assembled drugs for tumor diagnosis and treatment The research results were published in nature communications (DOI: 10.1038 / s41467-019-12848-5) under the title of "a tumour selective cascade activated self-detailed system for drug delivery and cancer imaging" Based on the concept of in vivo self-assembly, a novel tumor targeting mechanism is proposed for the first time, which brings new ideas for the design and potential clinical transformation of nanodrugs Traditional molecular drugs are not effective because they can be quickly eliminated by metabolism in vivo, while nano drugs can improve the solubility, tumor passive targeting and blood circulation time of drugs In the early stage, the team has been committed to the development of in-situ self-assembly of nanomaterials, systematically studied the process and mechanism of self-assembly of nano contrast agents and drugs in vivo, and explored its application in tumor imaging and treatment The "aggregation / assembly induced retention (air)" effect of materials is proposed, which can improve the retention time of contrast agents or drugs in the focus and enhance the diagnosis and treatment effect of the disease On the basis of previous work, the team constructed a new tumor selective cascade activated self detailed system (tcass) for tumor imaging and drug delivery In this system, small polypeptides specifically recognize the overexpressed X-linked inhibitor of apoptosis protein (XIAP) in tumors, which leads to the activation of Caspase-3 in tumor cells, which leads to molecular shearing, and the self-assembled nanofiber structure enhances the accumulation and retention in tumor tissues Meanwhile, the metabolic behavior of tcass is similar to that of small molecules, which can be rapidly excreted from liver and kidney, reducing systemic toxicity In order to optimize accumulation, infiltration and organ competition, the mechanism of effective accumulation and retention in tumor site was revealed, and the pharmacokinetics of the system was analyzed As a drug delivery system, tcass can not only enhance the therapeutic effect of traditional chemotherapy drugs, but also reduce the side effects The specificity and sensitivity of the contrast agent were significantly improved by coupling the contrast agent, which showed good imaging effect in the human bladder cancer model in vitro This study provided a new tumor targeting mechanism, accelerated the application of nanodrugs, and opened up new ideas for the basic research and clinical transformation of nanodrugs Dr an Hongwei, a graduate of the national Nano Science Center, is the first author of this research paper Academician Zhao Yuliang, researcher Wang Hao of the national nano science center and Professor Xu Wanhai of the Fourth Affiliated Hospital of Harbin Medical University are the corresponding authors of this paper This series of research is supported by international cooperation and cross team projects of NSFC and Chinese Academy of Sciences  
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