The Neural Basis and Genetic Effects of Maternal Negative Rearing Affecting Adolescent Depression

Adolescents are in a critical period of brain development, and are also a high-risk period when internalized symptoms such as anxiety and depression are rapidly increasing

In view of this, Li Xinying's research group at the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences and Qin Shaozheng's team at the State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, selected 100 from the Beijing Twin Study (BeTwiSt) Identical and 78 fraternal same-sex twins, a longitudinal study of more than 3 years was carried out to investigate the effects of maternal parenting in early adolescence (about 13 years old) on the development of the amygdala brain circuit and depression in the mid-teens (about 16 years old) The influence of symptoms, and clarify the proportion of genetic factors

Studies have found that the negative parenting >

Under the framework of "genetic-environment-brain function-psychological behavior", this study systematically investigated the influence of early adolescent mothers' parenting behaviors on the internalization of depression and other symptoms of middle-term adolescent depression through brain network function

The research work is supported by the National Natural Science Foundation of China, the Shandong Medical and Health Technology Development Program, and the Open Fund of the State Key Laboratory of Cognitive Neuroscience and Learning

Original title:

Negative parenting affects adolescent internalizing symptoms through alterations in amygdala-prefrontal circuitry: A longitudinal twin study