The new achievements of China University of Science and Technology have opened up the bottleneck of blood shortage

The research team and team of Cheng Linyi, a professor at The University of Science and Technology of China, have recently made important progress in the direction of in-body production of red blood cells, and for the first time have established an experimental system that amplifies a large number of red line progenitor cells from individual nuclear cells in human periter blood, and efficiently induces differentiation into mature red blood cells, while using mouse blood transfusion models to verify the function of red blood cells produced by the system, providing new ideas for solving the worldwide problem of red blood cell shortage.
present, red blood cells and other blood products mainly come from volunteer exo-weekly blood donation, insufficient donors, infection risk, rare blood type deficiency, etc. are still the world's blood transfusion problems. In-body induced ernicient stem cells are directed to differentiate into red blood cells, which is an important way to solve the above problems.Starting from the healthy provider's extraterritorial blood single nuclear cell-rich CD235a plus red line progenitor cells, the
Cheng Linyi task force, through detailed analysis of cells with different days of in-body amplification, found that the red line progenitor cells could not maintain self-renewal for a long time, and rapidly differentiated to the end, followed by apoptosis. High-volume sequencing results show that the BMI1 gene may play an important role in introphy and self-renewal of red line progenitor cells. They explored the function of BMI1 through both gene knock-down and re-filling, and proved that BMI1 is essential for in-body amplification and denuclearization of red line ancestral cells. In addition, they studied red-line ancestral cells from patients with sickle anemia and found that BMI1 had the same effect. Most importantly, a large number of amplified red line ancestral cells retain the potential for denuclearization, with an efficiency of up to 50%.
This result is the first to find that BMI1 can cause the insular amplification of red line ancestral cells up to one trillion times, and has the potential to differentiate and mature to produce functional red blood cells, confirming that in-body amplification of red line ancestral cells can be further genetically engineered to meet the needs of precision medicine.
related results have been published in Molecular Therapy.
, a professor at the New York Blood Center, believes the work is a breakthrough in the field of blood transfusions and solves the bottleneck problem of blood shortage. (Source: Gui Yun'an, China Science Daily)
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