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| The "100 ○ ○ Immunoomics Project" announces the latest results |
| The new "aging clock" can detect the risk of disease in time |
Science and Technology Daily, Beijing, July 12 (Reporter Zhang Mengran) According to the latest research published on the 12th in the British journal Nature Aging, scientists have developed a new "aging clock"-iAge using artificial intelligence, which provides for all mankind In order to detect new ways of increasing the risk of cardiovascular disease and other diseases in time, and to predict individuals whose risk of disease will increase
.
This tool uses blood-based signals that can induce chronic inflammation throughout the body, which is of great significance for early diagnosis and early intervention
Although the interaction between the immune system and many age-related diseases has been well characterized, there are few immune indicators that can be used to predict who is most at risk
.
The goal of the "1000 Immunoomics Project" is to study how the characteristics of chronic inflammation throughout the body change as we age
.
As part of this project, researcher David Forman and his colleagues at the Buck Institute for Aging in California, USA, studied blood samples of 1,001 people (aged 8 to 96; 66% were women)
The research team used artificial intelligence to develop a new immune index and called this inflammatory "aging clock" iAge
.
The "clock" is based on the concept that the level of specific immune cells and proteins in the blood fluctuates with aging; but for some people, this fluctuation occurs earlier, which is also defined as their iAge
The researchers also found that the chemokine CXCL9 is a protein that usually helps the immune system activate T cells, and its age-related release is also considered a key factor produced by endothelial cells that can accelerate the iAge clock
.
The chemokine CXCL9 produces the above-mentioned effects by promoting cell senescence.
The researchers believe that the iAge "clock" provides a new way to discover the risk of age-related diseases and decreased immune function in individuals, and proposed that CXCL9 and other iAge proteins are potential new targets for the treatment of these symptoms
