The new coronavirus has many changes, how the gene sequencing follows the rhythm

scientifically and effectively respond to the common global reality when challenged by large-scale global emergencies. The new crown pneumonia pandemic opens up tremendous opportunities for science and allows science to play its full role in this. Among them, the development of vaccines at lightning speed is the embodiment of core technical capabilities, as is genome sequencing.
11th, the World Health Organization held a regular briefing on new corona pneumonia, Director-General Tan Desser said that the wider the spread of the virus, the more likely it is to mutate. Crucially, we can effectively sequence viruses to understand how they change and how we respond. While diagnostic tools and vaccines are still effective against current viruses, we may need to adjust in the future.
week, WHO released a comprehensive implementation guidelines and risk monitoring framework to help countries build influential gene sequencing programmes.guidelines for genetic testing say the new coronavirus gene sequencing can be used in many different areas, including improved diagnosis, strategies and disease epidemiology.
early in the outbreak, the sharing of genome sequences for the new coronavirus led to rapid development of molecular diagnostic analysis, which improved global preparedness for outbreaks and helped countries develop responses. Fast, large-scale sequencing of viral genomes helps to understand the dynamics of virus epidemics and assess the effectiveness of prevention and control measures.
now, scientific developments have allowed us to sequence new coronavirus hours or days after a case is confirmed. Real-time genome sequencing can provide information for public health authorities' responses to pandemics.
more and more people realize that viral genome sequencing helps promote public health. As a result, more national laboratories are investing in this area. However, the guidelines say the costs and workload involved in genetic sequencing are enormous, and national laboratories need to have a clear idea of the expected public health returns from the investment.the
guidelines also warn that while gene sequencing has a "gateway", it is important that those who set goals, perform genomic analysis, and use results data be aware of the limitations of gene sequencing being dominated by certain forces, as well as potential sources of bias.guidelines give detailed guidance on how countries implement gene sequencing. Before starting a genetic sequencing program, it's important to have a clear understanding of the goal of sequencing, analysis strategies, and plans to use the results to provide information for public health responses, the guidelines say. Each phase of the new coronary pneumonia pandemic presents different challenges that are critical to public health, and addressing some of these challenges requires different genomic sampling strategies.
the relevant considerations for the implementation of gene sequencing, the guidelines state that decisions on gene sequencing objectives should be made within a multidisciplinary framework that includes senior representatives of all stakeholders. At the same time, to ensure sustainable support, the sources of funding required for sequencing should be identified, including the costs of experts, sequencing equipment and consumables, as well as the computing architecture required to process and store data. Laboratories should also carefully assess whether there are ethical issues. In addition, laboratories should conduct biosethics risk assessments at each step of their selected programmes.
in terms of the objectives of gene sequencing, laboratories should explain technical considerations for gene sequencing and sample selection methods. Currently, several devices can be used to sequence the genome of new coronavirus viruses. Each device may have some applicability under certain circumstances, depending on the accuracy of each read, the amount of data generated, and the turnaround time.
to achieve gene sequencing goals, virus sequence data and sample metadata are required in most cases. Getting this data and converting it to the correct analysis format can require a lot of resources, but it can also help maximize the potential impact of sequencing.
addition, the guidelines mention that how genetic samples are stored, tested, how integrity is preserved, and how data results are scientifically analyzed and interpreted to avoid misunderstandings need to be considered.
guidelines also state that no matter how many new coronavirus genome sequences are produced, they will have a positive impact on public health only if strategies are developed for the subsequent generation and dissemination of useful and timely results.if we are to better prepare for future threats, genome sequencing must be accelerated into the practice of the global health community," he said. "We hope that this guidance will help pave the way for preparation," said Sylvie Bryant, WHO's director of infectious disease hazard management, in the foreword to the guidelines. Many
rely on the ability to compare locally obtained virus sequences with global virus genome diversity, according to the guidelines. Therefore, proper sharing of viral genome sequences is critical, for example, in databases such as GISAID and GenBank, when global data sharing is in progress.
guide encourages countries to cooperate more complementaryly to ensure maximum capacity. For example, some countries may need to improve their capacity to build appropriate laboratories, while others may decide to outsource actual gene sequencing and focus on bioinsynomics, data management and data interpretation.
" strong and resilient global genetic sequencing network can maximize the impact of sequencing on public health, not only for new coronavirus, but also for future pathogens. The guide reads.
at a regular press conference on the 11th, Tandese also said WHO called on all countries to increase genetic sequencing of new coronaviruses and share the data globally to complement ongoing monitoring, testing and testing efforts.
virus has no borders, it is a common challenge facing us all of humanity. The nations of the world are a community of destiny, and no one can stand alone and overcome difficulties only by joining forces.