The new crown recoverer actually had a second infection, is it still useful to get a vaccine?

The patient's antibodies disappeared and he beed a secondary infection.
the principle of vaccines is to produce antibodies, does that mean that vaccinations don't stop infection? More data validation is required.
, however, the patient's diagnosis was lighter than the last symptom and produced antibodies more quickly, suggesting that even if the infection could not be stopped, the vaccine still had a significant role to play in protecting the infected person from reducing or not developing symptoms.
the world's first case of second confirmed infection with the new coronavirus in Hong Kong.
a 33-year-old Hong Kong man who was diagnosed on 28 March, discharged from hospital on 15 April, travelled to the United Kingdom and Spain on 6 August and returned to Hong Kong on 15 August, tested positive for nucleic acid and was admitted to hospital again for isolation.
Hong Kong Wireless News Screenshot Yesterday (August 24), researchers from the Department of Microbiology at the Li Ka-shing School of Medicine at the University of Hong Kong confirmed that the patient had been diagnosed again.
Compared to the patient's first and second infection of the virus strain gene sequencing, there are 24 differences, and the patient was admitted to the hospital has not detected antibodies in his body, so it was determined that he was re-infected after rehabilitation, rather than "fuyang."
In June and July of this year, a team of researchers from Chongqing Medical University and the Ucla School of Medicine showed that some of the new crown patients recovered and the antibodies in the body showed a downward trend or even disappeared.
, even if the antibody does not disappear, will it fail because of the virus variant? The researchers have raised questions about whether recovering patients will become infected again, and this time there are answers.
"it casts a very big shadow over the new crown," he said.
Li Lei, Ph.D. in Genetics at the University of The Chinese Academy of Sciences, commented, "We have always believed that the new crown infection will not be infected, and even we hope on the vaccine, but if infected with the virus can be re-infected, then the vaccine will lose a lot of meaning, the vaccine is to use inactivated or inactivated virus or virus fragments to simulate infection, if the real infection is not effective, then the simulated infection is meaningless."
, is it useful to get a vaccine?Hong Kong wireless news screenshot Antibody disappears, will it be even after vaccination will be infected again? According to local media reports in Hong Kong, the patient was diagnosed in Hong Kong on March 28 with mild symptoms such as cough, fever and headache, and was discharged from hospital on April 15 after two negative nucleic acid tests.
was hospitalized again on August 15, he remained asymptomatic, with normal body temperature and other health indicators, and no abnormalities were detected by chest imaging.
department of microbiology at the University of Hong Kong sequenced the virus samples he obtained during his two infections and found significant differences, including 24 different nucleotides.
Virus Taxonomics studies show that the first strain of infection is a "close relative" of a strain collected in the United States or the United Kingdom in March-April this year, while the second strain of infection is closest to the strain collected in Switzerland and the United Kingdom in July-August this year.
In an interview with the Hong Kong media, Du Qixuan, clinical associate professor in the Department of Microbiology of the University of Hong Kong, said: "Many people think that the life after infection immunity, there is no positive answer before, but this time I am pretty sure that the first infection can be a second infection at any time", he asked a question, the new coronavirus will be like influenza virus, long-term appearance in humans? He said the next step would be to study the causes of the disappearance of antibodies and secondary infections in the case.
Lu Mengji, a German-Chinese virologist and professor at the Institute of Virology at the University of Essen School of Medicine, said, "The upper respiratory tract is the exposed part of our body, immune cells can not function there for a long time, the surface of the endoskin cells re-infection is a natural process, especially the mediating antibody titularity down to a certain extent, to the virus organic can take advantage of."
previously, research teams had found that antibody levels in new coronary recoverers declined or even disappeared in the short term.
June this year, the journal Nature Medicine published a study from Chongqing Medical University, Chongqing CDC and other units, "Clinical and immunological assessment of asymptomatic infections of new corona pneumonia" (Clinical and immunological assessment of SARS-CoV-2 infections).
authors studied 37 asymptomatic infections and 37 confirmed cases of symptomatic symptoms and found that the antibody levels of the vast majority of infected people showed significant attenuation two to three months after infection.
81 percent of asymptomatic people had fewer antibodies in their bodies over an eight-week period, while 62 percent of people with symptoms had fewer antibodies.
less than 60 days, 40 percent of asymptomatically infected people had antibodies reduced to erratic levels.
and even those diagnosed with symptoms, 12.9 percent of patients had antibodies that were d't detectable.
the study believe that secondary infections are more likely if antibody levels in new coronary recoverers drop so quickly.
July, a small study of antibody levels published in the New England Journal of Medicine (NEJM) concluded similarly.
team at the University of California, Los Angeles (UCLA) School of Medicine accurately measured IgG antibodies in 30 patients diagnosed with new coronavirus disease (COVID-19) and four suspected patients, showing that nearly half of the antibodies disappeared after 73 days.
Du Qixuan believes that the case of secondary infection also has enlightenment to vaccine research.
the principle of vaccines is to make people who are vaccinated produce antibodies.
Du Qixuan said that the current vaccine is generally made out of antibody testing is very high, but over time, will even after the vaccine will be infected again? "It's going to take a little more data to know."
Hong Kong wireless news screenshots may not stop infection, but the vaccine still has a huge effect, but the disappearance of antibodies does not mean that immunity is gone;
although there is a re-infection, Lu Mengji said, "but the virus infection will induce immune cells to re-activate, in a very short period of time to start, so the virus will not spread to the lungs, causing serious symptoms."
from this case in Hong Kong, it can be seen that the patient's symptoms are reducing, the first infection with fever, cough and other symptoms, the second time did not appear any obvious symptoms.
Akiko Iwasaki, a professor of immunology at Yale University, cites an analysis that suggests that the immunity of the new coronavirus infection, while not preventing the patient from re-infection, is still effective in protecting the patient from COVID-19 symptoms.
Studies have shown that while the level of moderate antibody titration caused by a new coronavirus infection decreases significantly after 3-4 months of recovery, when the new coronavirus re-invades, the memory T and B cells in the body can quickly identify the invading virus and stimulate antibodies and cellular immune responses more quickly and effectively.
department of microbiology at the University of Hong Kong also found that when the patient was serologically tested on the 10th day after the first infection, no IgG antibodies against the new coronavirus were found in the blood.
, however, IgG antibodies against the new coronavirus have been detected on the 5th day after the second infection.
, the immune system of the new coronavirus has been "recognized" and can quickly produce targeted antibodies.
Li Lei, who has long argued that secondary infections are "very big shadows," also believes that lighter symptoms and faster antibody production are positive messages.
another positive message: This is the world's first case, what if it's an isolated case? Zhang Wenhong, director of the infection department at Huashan Hospital, also believes that there is still a case, there is no need to be too nervous.
commented on his microblog: "Re-infection" is about the durability of immunization, as well as the timing of future vaccine protection and the interval between repeated vaccinations.
This time after four months of re-infection, or a case, this problem should be observed in the larger post-infection population, the world currently has more than 22 million people infected, if "re-infection" is established, then in the new crown high-risk and endemic areas, re-infection will become the norm.
we'll wait and see, and we'll wait for further scientific reports from HKT.
N't need to be too nervous at the moment, after all, other coronavirus commonly found in history (such as the colds we often catch are caused by common coronavirus, there are currently four, and three of the more severe ARES, MERS and COVID-19) have been immunized for far more than four months.
Hong Kong "re-infection" news if true, after all, the world will continue to report, after all, this is a population immunity persistence problem, has universality, if the world is still not followed by a follow-up case report, this case of patient reporting will remain at the news level, rather than academic level.
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