The new discovery | Fish oil reverses the negative metabolism of a high-fat diet

a new study that suggests fish oil supplements can reverse harmful metabolic effects of a high-fat diet, such as type
2
diabetes, according to a new study published today in the journal
Journal of Physiology
.high-fat diet and metabolic disordersA high-fat diet has many negative effects, including weight gain, elevated cholesterol levels, insulin resistance, etc., and can lead to obesity and type
2
diabetes. After delving into the scientific mechanisms behind the effects of a high-fat diet on health, researchers have identified specific ways in which certain pathways play an important role. Metabolic disorders caused by a high-fat diet are associated with a variety of bio-chemical pathways, the most important of which are:liposin - which controls blood sugar levels and the breakdown and metabolism of fatty acids;fat cytokines - cytokines (cell messengers) produced in adipose tissue;lebinocytes
6
- cytokines involved in inflammatory responses;tumor necrotitis α - cytokines involved in inflammatory reactions;fatty acid synthesis - the process of converting excess carbohydrates into fatty acids; andlipids - the process by which fats are broken down to produce fatty acids.Fish oil and metabolic changes In recent years, fish oil has been hailed as a panacea for all diseases, considered a panacea for weight loss, fertility, skin health and energy gain, but not all of these "effects" are scientifically supported, although more and more studies have confirmed that fish oil can alter metabolic pathways.fish oil is rich in omega
-3
polyunsaturated fatty acids, including bicarbonate and 22 carbon hetase, which are known compounds that improve insulin sensitivity, strong anti-inflammatory, blood lipid and weight loss.in the new study, a team at the University of Sao Paulo in Brazil looked at how fish oil supplements affect the metabolic side effects of a high-fat diet on mice, led by
Maria Isabel Alonso-Vale
, an assistant professor in the Department of Biological Sciences. They first fed the mice around the fish oil supplement, then fed food containing high levels of fat and fish oil, and used the control group of mice that ate only high-fat foods. Once the diet was complete, they collected and analyzed fat samples from mice.researchers measured metabolic factors such as insulin resistance and fat deposits in different parts of the mouse's body.As expected, a high-fat diet causes significant changes in some metabolic pathways, including glucose intake and lipotin secretion, tumor necrotic cytokine α, leucocyte interleukin
-6
, lipolytic action, fat synthesis from the beginning, and the secretion of inflammatory cytokines., however, no such metabolic changes were seen in mice that ate fish oil supplements, in other words, the negative metabolic effects of a high-fat diet were halted by fish oil. The current study is being carried out in mouse models, so human trials must be conducted before the theory can be confirmed, as Professor
Alonso-Vale
put it, "We need more research to better understand the effects of fish oil on humans." "The results are very attractive and will no doubt lead to further investigation. Perhaps in the near future, fish oil will become an effective drug for metabolic diseases.