The new innate immune mechanism of tuberculosis resistant population to resist Mycobacterium tuberculosis infection

Tuberculosis ( tuberculosis , TB ) is a major infectious disease caused by Mycobacterium tuberculosis ( M.

In the past, it was believed that when healthy individuals were infected with Mtb , they often developed into latent infections or active TB patients

At present , little is known about the anti-infection immune mechanism of such TB resistant persons, and the in-depth revealing of the relevant mechanism is expected to provide new clues and new strategies for the prevention and treatment of TB .

A series of subsequent screening and functional verification experiments showed that during Mtb infection, histone deacetylase 6 ( HDAC6 ) only maintained a stable expression level and enzyme activity in macrophages derived from TB resistance, while There was a significant decrease in the population of other experimental groups

At present, the relevant results have been published online in The FASEB Journal , entitled "HDAC6 contributes to human resistance against Mycobacterium tuberculosis infection via mediating innate immune responses"

Figure 1: The innate immune mechanism of people with natural resistance to tuberculosis who rely on HDAC6 to resist Mycobacterium tuberculosis infection

Article link: https://faseb.