The new mechanism allows the body to "pretend" to eat less to activate stronger immunity against tumors

Science and Technology Daily (Reporter Liu Zhiwei, Correspondent Du Weiwei, Zou Yaqin, Wang Jianying) On June 25, the reporter learned from Wuhan University People’s Hospital that the “Tumor Metabolic Immunity” team of the hospital found that a drug can make the body “pretend” to eat less.

Earlier studies have found that "eat less" can enhance the body's immune surveillance, improve the body's ability to recognize, kill, and promptly remove mutant cells in the body, and it can also significantly improve the efficacy of immunogenic chemotherapeutics

The team found that a powerful autophagy inducer "picropodophyllin", by inhibiting the selective insulin-like growth factor 1 receptor (IGF1R), becomes a new calorie restriction mimic, which can improve the body's tumor response The role of immune surveillance, while increasing tumor immunogenicity, further activate the body's anti-tumor immune response ability

The research team therefore proposed that IGF1R may constitute a new drug treatment target

Related research papers were published in the famous international journal of tumor immunity "Journal of Cancer Immunotherapy", and were completed by Dr.