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    Home > Biochemistry News > Biotechnology News > The new method can synthesize nucleoside analogants for the treatment of viral infections and cancers faster and cheaper.

    The new method can synthesize nucleoside analogants for the treatment of viral infections and cancers faster and cheaper.

    • Last Update: 2020-09-16
    • Source: Internet
    • Author: User
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    But Professor Robert Britton, a chemist at Simon Fraser University in Canada, said: "This process is intensive and challenging, limiting and blocking the discovery of new drug therapies.
    , in a new study, Britton and his team were able to build new nucleoside analogoons months ahead of previous methods, paving the way for faster drug discovery.
    will also allow people to discover antiviral and cancer drugs faster and cheaper.
    study was published in the August 7, 2020 issue of the journal Science under the title "A short de novo synthesis of nucleoside analogs."
    nucleic acid similar to Redsiway chemical structure. Professor Britton said:
    The reduction in synthesis time and cost will vary, depending on the specific nucleotide analoga, but we have examples where we have reduced the number of synthesis steps that typically take at least a few months to complete in more than 20 steps to three or four steps, which will take about a week."
    is clearly a key factor in the treatment of newly evolved viruses such as SARS-CoV-2, the new coronavirus that causes COVID-19 disease.
    Britton team shortens this process by replacing natural carbohydrates commonly used to synthesize these drugs.
    Britton said: "This new approach creates opportunities for diversification of these drug stents and should stimulate the discovery of new and unusual nucleoside analogx drugs.
    " team also replaced naturally derived hand materials with handless materials because they were often cheaper and more versatile. "One of our priorities is to identify issues that limit the speed of drug discovery and development, especially with regard to the synthesis of custom nucleoside analogues," said Louis-Charles Campeau, co-author of the
    paper and head of process chemistry and discovery chemistry at Merck USA.
    we are delighted to be working with Professor Britton to develop new ways to acquire such important therapeutic molecules.
    " Reference: 1. Michael Meanwell et al. A short de novo synthesis of nucleoside analogs. Science, 2020, doi:10.1126/science.abb3231. 2.Gavin J. Miller. Unifying the synthesis of nucleoside analogs. Science, 2020, doi:10.1126/science.abd1283. 3.New process fast-tracks drug treatments for virals and cancer.
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