The new method of dosing is expected to reduce the rate of cancer recurrence

A U.S. research team has developed a new way to deliver chemotherapy and immunotherapy drugs to the tumor site by injecting special gels, promising to reduce the rate of cancer recurrence.
the study, the University of North Carolina team treated melanoma and a breast cancer previously less sensitive to immunotherapy based on animal models. The results showed that after the primary tumor was removed in mice, the therapy significantly reduced the recurrence rate of cancer. The study was published recently in
American Journal.
researchers say bio-compatible polymers can be mixed with crosslinkers to form gels in the body immediately, carrying the chemotherapy drug gisectabin and an immunochemical checkpoint inhibitor.
explained that the gel first increases the concentration of reactive oxygen that accompanies tumor growth, allowing immunotherapy drugs to better identify tumors. The concentration of reactive oxygen causes the gel to melt gradually and releases two drugs in a series. Chemotherapy drugs kill some cancer cells first, increasing the sensitivity of tumors to immunotherapy drugs. As the gel degrades, the reactive oxygen levels at the tumor site decrease, which helps inhibit tumor growth.
"It's an easy way to pry the biological characteristics of tumors and the body's autoimmune system at the same time as chemotherapy to inhibit tumor development and reduce side effects," gu Wei, an associate professor at the University of North Carolina at Chapel Hill and author of the paper, told the media. "
that this approach may also be effective for other tumors," he said. There's still a lot of work to be done before we go into clinical trials, but I think this approach is promising. Gu said. (Source: Xinhua News Agency Zhou Zhou)