The new strategy of radon nanoparticles enables the enhancement of lateral magnetic resonance imaging of tumors.

Reporter 26 from the Chinese University of Science and Technology was informed that the university's School of Chemistry and Materials Science Professor Liang Gaolin's team, to develop a gamma-glutamate enzyme (GGT) induced intracellular assembly of radon nanoparticles in situ strategy, and achieved a high-strength magnetic field under the tumor horizontal (T2) magnetic resonance imaging enhancement.
the results were published online March 25, 2019 in nanocoma, an internationally prestigiable academic journal.
glutamate peptidease is common in mammalian cells and bacteria, and is involved in the metabolism of endogenous glutathione and the balance of cysteine levels in the cell, playing an important role in maintaining the blood oxidation balance of cells.
, GGT may promote tumor development, invasion and drug resistance by regulating redox metabolism within cells.
studies have shown that many malignant tumors such as liver cancer, cervical cancer, ovarian cancer and breast cancer have overexpressed GGT.
as an important biomarker, THE specific detection of GGT can be used for early diagnosis of cancer.
magnetic resonance imaging (MRI) has a unique advantage in the diagnosis of deep tumors because of its non-invasive, high penetration depth and excellent spatial resolution.
However, the sensitivity of MRI is very low and a contrast agent is usually required to enhance the imaging contrast between normal and pathological tissues.
interesting, Liang Gaolin's team found that the nion nanostructure can be used as a new t2 magnetic resonance contrast agent under high-strength magnetic fields.
they designed a small molecular probe that could self-assemble and form nanoparticles within cells.
the small molecular probe is specifically cut by GGT on the cell membrane during the entry into the cell, then reduced by glutathione in the cell, and self-assembled in the cell by CBT-Cys click-shrink reaction.
mouse tumor live magnetic resonance imaging results showed that this in situ GGT-specific induced radon nanoparticlesignificantly enhanced the T2 weighted magnetic resonance imaging signal of mouse tumor.
this new T2 magnetic resonance contrast agent is expected to be used in the diagnosis of clinically related diseases, including cancer.
MAGNETIC Resonance Related Information Introduction: People's Daily reported that the first popular product "Mini Magnetic Resonance" in the expo closed a month later is still fascinating, Xinhua has more than one million views.
for a long time, large-scale medical diagnostic equipment has not been specifically designed and manufactured for infants and young children.
In clinical practice, newborns or premature babies are diagnosed with ultrasounds or X-rays.
but the former argument rate is too low, the latter has radiation risk is not suitable for early childhood diagnosis.
Hospital's Paediatrics, especially Infant intensive care centers, has been looking forward to a dedicated infant magnetic resonance imaging system to provide safe and accurate clinical diagnosis for young children. after many years of research and development,
Metsy Medical, in this year's first expo, released the world's first infant magnetic resonance products.
download APP read this article more in-depth coverage for a long time, large-scale medical diagnostic equipment is not specifically designed for infants and young children manufacturing systems.
In clinical practice, newborns or premature babies are diagnosed with ultrasounds or X-rays.
but the former argument rate is too low, the latter has radiation risk is not suitable for early childhood diagnosis.
Hospital's Paediatrics, especially Infant intensive care centers, has been looking forward to a dedicated infant magnetic resonance imaging system to provide safe and accurate clinical diagnosis for young children. after many years of research and development,
Metsy Medical, in this year's first expo, released the world's first infant magnetic resonance products.
Ambiaerocare is a global innovation company for cutting-edge medical imaging technology and medical big data, providing customers around the world with comprehensive medical imaging solutions, including the development, design, manufacture, sales, and artificial intelligence medical big data services of magnetic resonance (MRI), computed tomography (CT), digital X-ray machines (DRs).
the needs of the market, using its own technical advantages and research and development strength, launched the world's first baby-specific MRI system - Neona, a specially designed for 0-4 years of age infants and young children superconducting magnetic resonance imaging system, the system is delicate, can be directly placed in the infant intensive care unit, zero distance for infant diagnosis.
and the device imaging clear, high resolution, contrast is significant, fast, quiet, can provide doctors with accurate disease information, while giving premature babies to create a temperature, humidity, oxygen and other life-sustaining indicators of the best environment, by pediatricians alike. Professor William Bradley, a former president of the International Society for Magnetic Resonance Medicine and an American medical imaging authority, commented that "Neona will revolutionize infant diagnosis."
"The magnetic resonance of infants and young children provides safe, accurate and express methods for clinical diagnosis of infants and young children, and the market is huge, especially after China's opening of two children," said Professor Zhu Ming, a leading pediatric diagnostic expert at the
china's Pediatric Radiology Commission. "Neona is an innovative product designed for 4,000 hospitals in Europe and the United States and 1,300 tertiary hospitals in China, and more than 3,000 maternal and child health care centers," said Professor Ma Qiyuan, chairman of
.M.A., and former Professor Ma Qiyuan of Harvard Medical School.
it will be a boon for seriously ill infants and young children.
" the product in the expo will be widely concerned by the mainstream media, CCTV news broadcast, focus interview, news broadcast room, Phoenix Satellite TV, Xinhua News Agency, People's Daily headlines reported the product, local television stations have also featured reports, during the exhibition to see the pediatric machine style of the audience, NEONA became a medical device and medical and health care exhibition area of the net red and punching place.
to participate in the Expo around the medical institutions representatives and agents also flocked to, just a few days, they signed dozens of procurement intention, creating a bright spot into the Expo! The product will enter the domestic market early next year, and in Beijing, Shanghai and other well-known hospitals in the country's pediatrics and children's hospital priority use. introduction to
:Magnetic Resonance: Magnetic Resonance refers to the spin magnetic resonance phenomenon.
is broad in its sense, including nuclear magnetic resonance,NMR, electron magnetic resonance (paramagnetic resonance, EPR), or electron spin resonance (electron spin resonance, ESR).
in addition, magnetic resonance is often used in daily life as magnetic resonance imaging (MRI), a class of imaging devices made from the phenomenon of MRI for medical examinations.
development of historical magnetic resonance was discovered on the basis of solid microquantum theory and radio microwave electronics technology.
first observed the paramagnetic magnetic resonance in the hydromagnetic Mn salt solution in 1945, and the following year, the magnetic resonance of paraffin and protons in water was discovered by absorption and induction, respectively, and the ferromagnetic resonance of Fe, Co and Ni thin sheets was discovered by the method of harmonic-guided resonant cavity.
the anti-iron magnetic resonance of solid Cr2O3 was observed near room temperature in 1950.
observed the cyclotron resonance of electrons and caves in semiconductor silicon and palladium in 1953.
observed the sub-iron magnetic resonance in theoretical predictions and experiments in 1953 and 1955.
then discovered static magnetic resonance (1957) and spin wave resonance (1958) in the high-sub-pattern of magnetic ordering system.
began to study the phenomenon of magnetic resonance coupling of two magnetic resonances in 1956.
these magnetic resonances were discovered, they have been widely used in physics, chemistry, biology and other basic disciplines and microwave technology, quantum electronics and other new technologies.
such as paramagnetic solid quantum amplifiers, various ferrite microwave devices, MRI-spectrum analysis techniques and MRI technology, and the use of magnetic resonance methods to the crystal and energy level structure of paramagnetic crystals, the energy belt structure of semiconductors and biomolecular structure.
the determination of spin and magnetic moment parameters of nuclei and elementary particles is also developed on the basis of various magnetic resonance principles.
magnetic resonance imaging technology is widely used in clinical medicine and medical research because of its radiation-free and high resolution.
some of the most advanced equipment manufacturers work with researchers to continuously optimize the performance of magnetic resonance scanners and develop new components.
examples: Siemens 1.5T superconducting magnetic resonance scanners in Germany have neuroimaging components, vascular imaging components, cardiac imaging components, body imaging components, tumor program components, bone joints and children's imaging components.
it has the advantages of high resolution, uniform magnetic field, fast scanning speed, relatively small noise and multi-directional imaging.
Source: Science and Technology Daily, Sino-Singapore Latitude.