The new study will help determine the mesothelial properties of micro-needles in different materials

, Beijing, August 28 (Xinhua) -- Micro-needle mesothional drug is a new drug-giving technology that has emerged in recent years and has the advantages of painlessness. What is the performance of micro-needles of different materials dissolving and dissoluting under the skin? Chinese researchers have proposed a new evaluation method in a paper published in the new issue of the International Journal of Polymer and Polymerized Biomass.
microneedle persetretic administration is the release of drugs through the skin through tiny needles, because the length of microneedles is generally between 10 microns to 1 mm, will not stimulate the nerves, compared with traditional injections have painless advantages. Compared with oral drugs, micro-needle transderscopic administration also has the advantages of avoiding liver over-effect and providing stable blood concentration. As a result, in recent years the scientific community has developed micro-needles of a variety of materials, including soluble micro-needles made of biodegradable materials, which are used without medical waste.
how do you compare the performance of different micro-needles dissolving and dissoluting under the skin? The
, led by Gao Yunhua, a researcher at the Institute of Science, Technology and Technology in China, proposed a rapid detection of micro-needle moisture absorption to determine the solubility of the material.
team selected 15 kinds of micro-needle substation materials commonly used at present, and used high-volume dynamic moisture adsorption technology to obtain moisture absorption data from different micro-needle materials. Moisture absorption is an important index to evaluate the performance of soluble micro-needles. Studies have shown that polyglutinine microneedots have the strongest moisture absorption capacity, and polyvinyl alcohol microneedots and hydroxypropyl cellulose microneeds have the weakest moisture absorption capacity.
study also showed that for the weak moisture absorption of polyethylene alcohol micro-needle, if added to the small molecule solvent, its moisture absorption and solubility increased, the dissolution rate increased by about 10%.
The results of this research will help the relevant industries to screen out more effective micro-needle materials, provide new evaluation methods to explore the effects of micro-needle materials on drug perderic release, and promote further development in the field of micro-needle mesothelial administration," said Zhang Lockhui, a member of the team. According
, micro-needle mesothion administration has a broad application prospect in the treatment of the use of biometric drugs, and is expected to replace traditional injection methods in the application of some drugs. At present, micro-needle mesothional drug treatment technology in diabetes treatment, vaccination and other aspects of more in-depth research and certain applications.