The new ultrasonic nerve control chip establishes an experimental system that is compatible with the records of the offlier meninges diaphragm clamps.

Recently, Zheng Hairong's team at the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, made new progress in ultrasonic nerve regulation, and the research on On-Chip Ultrasound Modulation of Pyramid Al Neuron Activity in Hippocamp S. Slices was published in advanced Biosystems and selected as the front cover article.
in recent years, ultrasonic neuroregulation as a new non-invasive neuroregulation technology has received wide attention, which is expected to provide a new clinical solution for the intervention and treatment of neuropsychiatric disorders.
Zheng Hairong's team carried out comprehensive research on the internal mechanism and intervention of ultrasonic regulation of neurons, beautiful hidden rod nematodes, rodents and non-primates, and developed a variety of cross-scale ultrasonic nerve control instruments.
: Using a new ultrasonic nerve stimulation chip compatible with the exosome electrophysiological recording system (a-b) of the offlia brain chip, the study shows that different ultrasonic intensity stimulation can directly cause the neuron membrane potential depolarization, induced action potential (c-d). The internal mechanism of ultrasonic nerve regulation is not clear
, and due to the large size of the traditional ultrasonic probe and the poor compatibility with electrophysiological and calcium imaging systems, the study of ultrasonic nerve regulation mechanism is further limited.
the researchers designed and used a new ultrasonic nerve stimulation chip developed in the ory, established an experimental system compatible with the recording of the isomer meninges diaphragm clamps, and took the exosome hippocampus brain as the research object.
results show that under the action of ultrasound, the hippocampus neurons can be activated by ultrasound to produce action potential, and with the increase of ultrasonic strength, the frequency of action potential release is increased accordingly.
, the mechanical effect of ultrasonic stimulation can directly enhance the internal flow of sodium ions in neurons, thus significantly increasing neuronal excitability.
, ultrasound stimulation changes the biodynamics of the sodium channel and thus improves the channel opening efficiency.
in the channel activation process, ultrasonic stimulation significantly reduces the channel activation threshold, during channel inactivation, ultrasonic stimulation significantly accelerates the channel inactivation rate, and during channel recovery, ultrasonic stimulation significantly reduces the channel reply time. The significance of the work of
lies in the development of a new type of ultrasonic nerve regulation chip, the use of diaphragm clamp recording means to systematically study the regulatory effectofle of ultrasonic stimulation in a single neuron and ion channel level, for the further study of ultrasonic nerve regulation mechanism provides a new way of thinking and a powerful tool for the final service of clinical foundation.
the above-mentioned research work is supported by the National Science Foundation of China national major scientific research instrument research project, the National Natural Science Foundation project, the Jieqing project in Guangdong Province and the discipline layout of Shenzhen.
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