The nutritional intervention method of mouse multiple sclerosis model is proposed.

There is a complex interrelation relationship between nutrition and immunity, and dietary interventions have been shown to be effective in preventing metabolic diseases and delaying the aging process.
multiple sclerosis is a common autoimmune chronic inflammation and demyelination disorder.
recently, Dr. Chen Wei of the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences and others used models of mice with multiple sclerosis to study the interventional effects of intermittent dieting.
the study used a polypeptide-immune mouse with myelin-less glial cytosaccharides to induce multiple sclerosis, and analyzed the interventional effects of intermittent dieting programs on multiple sclerosis.
In the 4th week after immunization, after the symptoms of multiple sclerosis became apparent, 1/3 of the normal mice were fed a hot card for 3 days, followed by free eating for 4 days, with a total of two cycles of intervention.
Compared to mice without calorie restriction, the severity of multiple sclerosis in mice on intermittent dieting, the immersion of immune cells in the spinal cord, and the degree of demyelination of the central nervous system were significantly improved.
In addition, the study explored the mechanisms by which intermittent dieting alleviates multiple sclerosis, and found that intermittent dieting increased the rate of proliferation of less protrusive glial cells in the spinal cord and enhanced the expression of brain-based neurotrophic factors and myelin regenerative markers.
studies have shown that intermittent calorie restriction can improve the development of multiple sclerosis in mice by improving inflammatory responses and promoting the recovery of damaged tissue.
results, published in the nutrition journal Journal of Nutrition Biochemistry, are based on intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis.
research has been supported by the National Natural Science Foundation of China, the Ministry of Science and Technology and the Chinese Academy of Sciences.
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