The old heart disease digoxin drug "new use" may be used to treat brain cancer in children.

Myeloblastoma is the most common malignant brain tumor in children, accounting for 20% to 25% of childhood brain tumors.
, researchers at Jackson's Lab, Connecticut Children's Medical Center and the University of Connecticut Health Center recently found that a drug for heart disease may also be effective in brain cancer in children.
the results were published in the journal Science Translational Medicine under the title "Systems Biology-based drug re-researchis digoxin as a' saitad for groups 3 and 4 medulloblastoma".
the current treatment of myeloblastoma significantly improves survival rates, many children face adverse effects of treatment on their brains, hormones and fertility later in life.
there are a small number of patients who either do not respond to existing treatment options or suffer and die from relapse.
is in urgent need of better drugs to treat myelin cell tumors with fewer side effects.
but it is well known that developing new cancer drugs is a time-consuming process that requires years of clinical research and at least 10 months of FDA approval.
now, thanks to a new methodology, it is expected to speed up the process.
team found that drug data collected during the FDA's first approval process could be reanalyzed to find a cross between diseases that the drug may treat.
process, known as systemic drug repositioning, uses computer modeling methods to compare the gene expression spectrum of approved drugs and then compare them with active genes in patients with the disease.
but myelin cell tumors are very complex, and there are often very different patients, even within a patient.
Ching Lau, co-appointed professor at the University of Connecticut School of Health and Connecticut Children's Medical Center, director of pediatric hematology oncology at the University of Connecticut School of Health, and medical director of the Pediatric Hematology Oncology Department in Connecticut, believes that the repositioning of the system's drugs can lead to better drugs for the treatment of myelin mablastoma.
but in his view, the technology could be improved.
Ching Lau, working with researchers from other agencies, has devised a new systematic drug repositioning method that can treat complex diseases such as myelin.
their new method has identified eight drugs that may treat myelin, three of which have been used to treat other cancers and five for heart failure.
researchers also found that a heart drug called digoxin could help mice with myelin to live longer.
mice survived longer when digoxin was used in combination with radiation. "This is exciting because not only does we potentially increase the overall survival rate of patients with digoxin treatment for myelin, but the results also show that we can potentially reduce the radiation dose required when used in combination with digoxin, thereby reducing the long-term side effects of radiation on survivors," Lau said.

"Because digoxin has been used to treat heart failure for many years, its potential side effects are well known. "In other words, digoxin's therapeutic potential as myelin is very promising for pediatric cancer patients, "
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Source: Biological Exploration.