The old man took medicine to avoid grapefruit.

Original title: the elderly take medicine to avoid grapefruit
grapefruit, also known as grapefruit, juice tasteful beauty, rich in vitamins, and we often say grapefruit is not a kind of fruit. However, in recent years, domestic and foreign literature has reported that more than 80 kinds of drugs can interact with grapefruit, of which more than 40 can have serious side effects, and most of them are commonly used drugs in middle-aged and elderly people.
This is because grapefruit inhibits the decomposition of the drug in the intestines, causing the drug to enter the bloodstream at the usual doses of several or even dozens of times, causing the drug to accumulate in the body, increase adverse reactions, and even have toxic or unpredictable clinical consequences. Therefore, the elderly after taking some medicine to avoid eating grapefruit, especially do not drink grapefruit juice. So, what drugs are being taken for the elderly to pay attention to?
first, lipid-lowering drugs (statins) and grapefruit are used together to increase liver and muscle toxicity. Statins are the most widely used type of fat-lowering drug, and the active ingredient in grapefruit greatly increases its concentration in the blood. The study found that patients with hyperlipidemia were 10 to 15 times higher than those who took a glass of lovastatin with a cup of grapefruit juice.
second, anti-hypertensive drugs (calcium ion antagonists) and grapefruit, resulting in low blood pressure. Antihypolycemic drugs that interact significantly with grapefruit are mainly "geo-flat", such as non-loddi, nitrobenzene. Eating grapefruit during taking the drug, equivalent to increasing the amount of medicine, leading to a sudden drop in blood pressure, so that patients appear unwell, light dizziness, panic, fatigue, serious people induced angina, myocardial infarction or stroke.
, sedative hypnotics and grapefruit are used together to exacerbate sleepy side effects. Grapefruit inhibits the metabolic process in the body, such as diazepam, medazoleon, and so on, aggravating drowsiness, dizziness and other after-effects symptoms, resulting in a "hangover" phenomenon. Drivers and high-risk precision operators need to be especially careful.
, immunomodulatives (cyclosporine, tekmos) and grapefruit were served together to increase liver and kidney toxicity. Grapefruit increases the blood concentration of immunosuppressants such as cyclosporine and increases liver and kidney toxicity. Grapefruit juice can also significantly increase the absorption of cyclosporine in the intestines, inducing tumor risk.
, the drugs affected by grapefruit also include some anti-allergy drugs, anticoagulants, gastric power drugs and so on. After eating grapefruit is often 3 to 7 days to completely remove from the body, for safety reasons, it is recommended to take the drug 3 days before, during the period of medication and stop the drug within a week to avoid large quantities of consumption.
grapefruit, the study also found that pomegranate juice, cranberry juice, orange juice and other drugs absorption and metabolism also have varying degrees of influence. It is recommended that elderly people who take a variety of drugs consult a pharmacist to avoid risks.
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