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Coronaviruses with a SARS-CoV-2-like receptor-binding domain allowing ACE2-mediated entry into human cells isolated from bats of Indochinese peninsula, DOI: 10.
10.
In this new study, researchers from the Pasteur Institute in France and the University of Laos captured 46 species of 645 bats and collected 247 from July 2020 to January 2021 in the limestone "karst zone" in northern Laos.
Genome description of bat-borne sarbecovirus found in Laos
Genome description of bat-borne sarbecovirus found in LaosResearchers attention spike protein sequences of the new virus crown surface, the spike protein receptor binding domain (the RBD) receptor by human cells, " vascular angiotensin converting enzyme 2 (ACE2)" bind to invade the human body
Blood vessel
Recombination events in the evolutionary history of sarbecoviruses
Recombination events in the evolutionary history of sarbecovirusesIn previous studies, the RaTG13 bat coronavirus found in China is the closest to the new coronavirus, and the genomes of the two viruses share 96.
Therefore, there is a key issue in the traceability study of the new coronavirus that needs to be solved, that is, whether there is a bat coronavirus on its spike protein that has an RBD gene sequence similar to that of the new coronavirus and can bind to the human ACE2 receptor with high affinity
Infect
The researchers pointed out that the viruses code-named BANAL-52, BANAL-103 and BANAL-236 are "the closest known to the new coronavirus to date" bat coronavirus
Mark Eloyt, one of the authors of the paper and the head of pathogen exploration at the Pasteur Institute, said that these three bat coronaviruses may be the source of the new coronavirus and may pose a substantial risk of direct transmission to humans.
The researchers also made it clear that their analysis showed that the evolutionary history of the new coronavirus is more complicated than expected, and the RaTG13 virus found in China cannot now be considered the nearest ancestor of the new coronavirus
Researchers believe that the genome of the new coronavirus may be the result of multiple reorganizations of coronaviruses carried by different types of bats
Researchers believe that the genome of the new coronavirus may be the result of multiple reorganizations of coronaviruses carried by different types of bats
Reference: Coronaviruses with a SARS-CoV-2-like receptor-binding domain allowing ACE2-mediated entry into human cells isolated from bats of Indochinese peninsula, DOI: 10.
Reference: Coronaviruses with a SARS-CoV-2-like receptor-binding domain allowing ACE2-mediated entry into human cells isolated from bats of Indochinese peninsula, DOI: 10.
21203/rs.
3.
rs-871965/v1 10.
21203/rs.
3 .
rs-871965/v1
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