echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Infection > The Pasteur Institute of France has discovered the closest coronavirus to the new coronavirus in Laos

    The Pasteur Institute of France has discovered the closest coronavirus to the new coronavirus in Laos

    • Last Update: 2021-09-29
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Coronaviruses with a SARS-CoV-2-like receptor-binding domain allowing ACE2-mediated entry into human cells isolated from bats of Indochinese peninsula, DOI: 10.


    10.


    In this new study, researchers from the Pasteur Institute in France and the University of Laos captured 46 species of 645 bats and collected 247 from July 2020 to January 2021 in the limestone "karst zone" in northern Laos.


    Genome description of bat-borne sarbecovirus found in Laos

    Genome description of bat-borne sarbecovirus found in Laos

    Researchers attention spike protein sequences of the new virus crown surface, the spike protein receptor binding domain (the RBD) receptor by human cells, " vascular angiotensin converting enzyme 2 (ACE2)" bind to invade the human body


    Blood vessel

    Recombination events in the evolutionary history of sarbecoviruses

    Recombination events in the evolutionary history of sarbecoviruses

    In previous studies, the RaTG13 bat coronavirus found in China is the closest to the new coronavirus, and the genomes of the two viruses share 96.


    Therefore, there is a key issue in the traceability study of the new coronavirus that needs to be solved, that is, whether there is a bat coronavirus on its spike protein that has an RBD gene sequence similar to that of the new coronavirus and can bind to the human ACE2 receptor with high affinity


    Infect

    The researchers pointed out that the viruses code-named BANAL-52, BANAL-103 and BANAL-236 are "the closest known to the new coronavirus to date" bat coronavirus


    Mark Eloyt, one of the authors of the paper and the head of pathogen exploration at the Pasteur Institute, said that these three bat coronaviruses may be the source of the new coronavirus and may pose a substantial risk of direct transmission to humans.


    The researchers also made it clear that their analysis showed that the evolutionary history of the new coronavirus is more complicated than expected, and the RaTG13 virus found in China cannot now be considered the nearest ancestor of the new coronavirus


    Researchers believe that the genome of the new coronavirus may be the result of multiple reorganizations of coronaviruses carried by different types of bats


    Researchers believe that the genome of the new coronavirus may be the result of multiple reorganizations of coronaviruses carried by different types of bats


    Reference: Coronaviruses with a SARS-CoV-2-like receptor-binding domain allowing ACE2-mediated entry into human cells isolated from bats of Indochinese peninsula, DOI: 10.


    Reference: Coronaviruses with a SARS-CoV-2-like receptor-binding domain allowing ACE2-mediated entry into human cells isolated from bats of Indochinese peninsula, DOI: 10.
    21203/rs.
    3.
    rs-871965/v1 10.
    21203/rs.
    3 .
    rs-871965/v1

    Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.