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1 Physical and chemical properties and uses
β-agonists (β-agonists) belong to the phenethylamines (phenethylamines, PEA), which are chemical analogs of catecholamines , epinephrine and norepinephrine
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It has a phenethanolamine structure core, the substituents contained on the benzene ring include β-hydroxyamine (secondary amine) side chain, and the substituents on the side chain are generally -tert-butyl, N-isophenyl or N-alkyl Benzene can form salts with acids
Figure 1-1 Basic structure diagram of β-receptor agonist
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1 Physical and chemical properties
Beta-receptor agonists are mostly white or off-white crystalline powder, often in the form of hydrochloride or sulfate
.
The physical and chemical properties of common drugs are shown in Table 1-1
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2 Purpose
(1) Treatment of respiratory diseases
β-receptor agonists are also known as β-adrenergic receptor agonists.
They are mainly used in medicine or veterinary medicine to expand the bronchi and increase lung ventilation.
It can treat bronchial asthma, obstructive pneumonia, smooth muscle spasm and Shock and other illnesses
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The tissue β- agonists - selective different physiological range will β- receptors are divided into beta] .
(2) Redistribution effect
β-receptor agonists also have a "redistribution effect" in the body
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Through a large number of studies on mice, cattle, sheep, pigs and other animals, it has been found that the use of β-agonists can significantly increase the weight of animal skeletal muscle and reduce the weight of fat, but it has no significant effect on the overall body weight, and It has an effect on animals of different sexes, different ages, and different kinds of animals
