The pore-forming protein complex promotes scar-free tissue repair.

Organizational restoration is a common problem that animals face during their survival. The formation of
scar tissue is a common by-product in human trauma repair, which can lead to serious clinical dysfunction and appearance problems, how to promote tissue regeneration repair while avoiding and reducing scar formation is an important issue that people try to explore.
the skin of amphibians to assume the important physiological functions of breathing and water salt balance, and its trauma repair must be scarr-free, so as not to impair the corresponding physiological function and cause fatal consequences.
unlike the familiar membrane receptors, ion channels, transporters and other traditional membrane proteins, pore-forming protein is a kind of non-classical membrane protein, characterized by the existence of a secreted monomer soluble form, under certain conditions through oligate and then inserted into the cell membrane system.
the current understanding of a large number of pore-forming proteins present in plants and animals mainly focuses on their cellular toxicity, and little is known about the physiological pathological functions and cellular pathways they are responsible for. Zhang Yun
, a researcher with the Biotoxin and Human Disease Seology Group at kunming Institute of Zoology, Chinese Academy of Sciences, discovered the first new type of pore-forming protein and trilobite complex betagamma-CAT (invention zl patent 200810058028.5 in Yunnan amphibian sempuce; PLoS One, 2008,3,e1770), and found that the endogenous protein machine has the characteristics that stimulate cell follicle production, form membrane channels in intracellular swallowing/lysozymes and regulate its function (Proc Natl A SciCAD USA 2014, 111,6702, cover story; J Infect Dis 2017, 215, 1753).
recently, the group Gao Zhenhua and other further in-depth revealed that the compound has the function of stimulating tissue repair.
compared with the epidermal growth factor EGF, which is widely used in the clinic, the compound can not only promote wound healing by speeding up the rebutionization of skin tissue damage, but also has the characteristics of reducing traumatic edema, promoting scar-free healing, and resisting drug-resistant bacterial infection.
the study found an unknown protein effect molecular complex and a new cell action pathway for tissue trauma repair in vertebrate tissue, which provides new ideas and clues for the in-depth analysis of the molecular pathological mechanisms of tissue regeneration and repair and scar formation, and has practical significance for the development of new disease treatment drugs.
research results, entitled Pore-forming toxin-like protein complex ext. by frog promots tissue, are published in the Journal of the American Society of Experimental Biology (ASEB Journal), with Gao Zhenhua as the first author, Zhang Yun and Associate Researcher Li Sheng'an as the newsletter authors.
the research was supported by the National Natural Science Foundation-Yunnan Joint Fund's key projects, the Yunling Scholars Program and the "Western Light" project of the Chinese Academy of Sciences.
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