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    Home > Biochemistry News > Biotechnology News > The principle, advantages and application of gene silencing spray.

    The principle, advantages and application of gene silencing spray.

    • Last Update: 2020-09-06
    • Source: Internet
    • Author: User
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    Don't you think the color of the roses in the yard is tonight? Replanting is too "labour and people hurt money".
    you might one day be able to buy a spray on the market and change the color of the flower by silencering a particular gene with a single spray on the flower.
    the following small compilation for you to introduce in detail about the principle, advantages, application of gene silencing spray.
    this magic spray is a "good news" for farmers.
    by using similar gene silencing sprays, farmers can easily increase crop yields, increase nutrients, increase drought resistance and induce them to precocious.
    particularly appealing is that this gene silencing technique can both change the nature of plants and avoid "hands-on feet" on their DNA, dispels concerns.
    " spray is ready-to-use and does not require years of research and development, unlike genetically modified or traditional breeding techniques.
    "says David Baulcombe, a long-time researcher on plant gene silencing at the University of Cambridge.
    he also noted that the gene silencing spray may also be suitable for a variety of plants.
    sounds amazing, the spray is real.
    companies that have been at the forefront of global biotechnology advances, such as Monsanto, are now starting to attack gene-silencing sprays in the hope of eliminating crop pests and diseases by silencing specific genes.
    so-called gene silence, in fact, the use of an all-natural defense system.
    when a virus invades a cell, the cell cuts the virus's RNA into short fragments, forming a double-stranded RNA that identifies and destroys matching RNA sequences within the cell.
    viruses that lack RNA cannot produce proteins and naturally cannot replicate them.
    this is what is commonly referred to as RNA interference technology (RNAi).
    RNA interference technology can be used to prevent the production of any protein.
    But unfortunately, on the medical front, drugs currently developed on the basis of RNA interference technology have not yet made leapfrog progress, mainly because RNA injected into the blood tends to degrade rapidly and then become inactive.
    many genetically modified plants work by actually producing RNA that silences genes.
    more importantly, biologists have found that spraying small molecule double-stranded RNA that matches a particular gene sequence can also easily shut down specific genes in some, if not all, of the diseased insects and plants.
    , founded in 1901, was originally a company that produced sacchar products.
    , Monsanto has made breakthroughs in fertilizer, crop protection, and plant genetics, opening the way to innovation in agriculture.
    1990s, Monsanto began promoting genetically modified corn, soybeans, rape and other genetically modified crops around the world.
    , Monsanto, which has been at the forefront of biotechnology, is the first to develop RNA interference sprays to control pests and diseases.
    , developed by Monsanto, specifically targets shingles, one of the world's most threatened bee pests and diseases in the beekeeping industry.
    , according to Monsanto's public report earlier this year, the development of the spray to eliminate the shingles is now in its final stages.
    is said to be the "final stage" because the spray now faces a very difficult challenge to overcome: because the RNA in the spray is easy to break down, this makes the spray effective enough to last long enough, in the plant insect resistance can only last for a few days.
    means frequent use of spray, and expensive spending will undoubtedly place a heavy financial burden on farmers.
    to provide long-lasting protection technology will always surprise people.
    comes at a time when biologists around the world are thymtic about the unsustainable ability of gene silencing sprays, a team of researchers from the University of Queensland in Australia has offered new ideas and possibilities.
    According to Nature Plants, a team at the University of Queensland in Australia has succeeded in achieving long-term silencing of genes in plant cells - by spraying the gene silence spray once, they have made tobacco plants resistant to the mildly mottled virus in chili peppers for up to 20 days, setting an all-time record.
    believe it is a key advance towards environmentally sustainable crop protection," he said.
    team member Neena Mitter commented on the team's work.
    , many current research teams around the world have been studying the long-term effects of plants, but the Mitler team was the first to publish the study.
    , how on earth did the Mitter team make gene silencing sprays long-lasting? According to the editor, Mitter and colleague Gordon Xu achieved this long-lasting effect by combining RNA with clay nanoparticles.
    In terms of specific operations, the researchers first used common compounds, such as magnesium chloride, to prepare clay nanoparticles stacked in layers and positively charged, and then combined clay nanoparticles with negatively charged RNA to provide protection.
    over time, moist clay nanoparticles react with carbon dioxide in the air and break down gradually, slowly releasing RNA for lasting effect.
    It's an exciting result," said John Killmer, founder of biotech company Apse, "in addition to pest control and disease, the new spray will also open up a variety of plant 'modification' trends", such as those used to change the color and appearance of plants.
    but the Mitmer team is not currently involved in the field, focusing only on crop disease prevention and protection.
    safety advantages highlighted, plant pests and diseases are a huge problem for farmers around the world.
    Since existing technologies do not directly target these pests and diseases, farmers can only choose to breed insect-resistant varieties, if any, or try to eliminate microorganisms that can spread plant viruses, such as aphids.
    therefore foreseeable, once this gene-silencing disease-resistant spray can achieve the same remarkable results in field trials as in the laboratory, there is bound to be a huge demand.
    "We believe its commercialization is feasible."
    " Mitter is confident.
    , however, this gene-silent disease-resistant spray must overcome an obstacle that can't be overcome - cost - if it is to truly embark on a path to commercialization.
    although the cost of producing clay nanoparticles is very low, the cost of synthetic RNA is extremely high.
    years ago, it would have cost more than $100,000 to produce 1 kern of RNA.
    even now, the cost of RNA remains at $100 to $200 per g.
    , this situation is changing rapidly with the continuous progress of science and technology.
    now, Killmer's Bio is working on a technology that produces RNA on a large scale and is expected to reduce its costs to less than $2 per g.
    , gene silencing sprays are safer than commonly used insecticides.
    RNA is not absorbed by the body's skin and degrades quickly once it enters the body.
    , however, previous studies have claimed that RNA from some plants ingested by humans through food has had an effect on human genes, but several subsequent studies have found no evidence of such an effect.
    "I don't have any worries at all."
    , the combination of RNA and clay nanoparticles does not pose any safety risks, according to Baulcombe.
    In addition to the safety advantages mentioned above, another advantage of gene silencing techniques is that they are effective by altering RNA sequences, which may avoid effects on non-targeted organisms and overcome most forms of resistance as much as possible.
    for now, the technology also seems to have crossed the line between itself and GM technology, at least for now, as many in reverse camps have welcomed the new technology.
    I got a call from an organic crop grower who wanted me to hurry up with the technology," he said.
    ," Killmer said.
    , gene silencing sprays are not "lone stars" in this direction.
    other biologists are also looking for other sprays that can alter plant characteristics, such as relying on plant signaling molecules.
    .
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