The principle of action of "three drugs and three parties" in the treatment of COVID-19

Zhu Yan/Lu Ming's research group of the State Key Laboratory of Component Chinese Medicine of Tianjin University of Traditional Chinese Medicine published a review article in the Scientific Bulletin, introducing the research progress of traditional Chinese medicine represented by "three medicines and three parties" in the treatment of COVID-19 clinical and pharmacology, and scientifically summarized and systematically summarized its potential principle of action, aiming to deeply understand the positive role of traditional Chinese medicine in the prevention and treatment of COVID-19 and promote the international development
of traditional Chinese medicine.

The worldwide outbreak of corona virus disease (COVID-19) has caused millions of deaths and caused huge losses
to people's health and property worldwide.
China has achieved remarkable results in the prevention and control of the epidemic, among which the "three medicines and three parties" of traditional Chinese medicine selected and refined by many academicians and experts through clinical practice, including Jinhua Qinggan granules, Lianhua Qingpeng capsules, Hebijing injection and lung detoxification soup, wet and septic poison formula, and Xuanlung detoxification party, have played an important role
.

Chinese medicine is good at exploring the pathogenesis of diseases from a holistic perspective, including the disease itself and the influence of
the human internal and external environment.
COVID-19 itself belongs to the category of "plague" in Chinese medicine and is highly contagious and epidemic.

Zhang Boli's research team classified the characteristics of his case as "wet poison epidemic", the basic disease mechanism is manifested as the external invasion of epidemic poison, the lung undergoes evil, and the deficiency of righteous qi, and the pathological properties are dampness, heat, poison, deficiency and stasis, so the main treatment is
to detoxify wet and detoxify and eliminate filth and turbidity.

"Three Medicines and Three Parties" as a recommended drug for the treatment of COVID-19 has been widely used in clinical practice, through the induction of its composition, it was found that ephedra, raw plaster, honeysuckle, forsythia, skullcap, bitter almond and other traditional Chinese medicines have been used many times, most of which have the effect of clearing heat, dehumidifying and detoxifying, respectively, attributed to the lungs, stomach, heart, liver or spleen
.
COVID-19 is primarily caused by an immune response and an inflammatory storm triggered by viral infection of the lungs, and is characterized by
multi-organ damage.
The scope of application of "three drugs and three parties" covers the entire course of COVID-19, including the period of medical observation and the confirmed period of mild, moderate, severe and critical cases, as shown in Figure 1
.

Figure 1.
The application of "three drugs and three parties" in different stages of COVID-19 treatment

"Three medicines and three parties" can not only alleviate fever, cough, fatigue, phlegm, diarrhea, loss of appetite, chest tightness and shortness of breath and muscle soreness; It can also shorten the time of nucleic acid to negative, prevent the disease from getting worse, improve the characteristics of lung CT images, alleviate lung inflammation, adjust clinical biochemical indicators, and reduce a series of complications
.
The principle of action of "three drugs and three parties" in the prevention and treatment of COVID-19 mainly involves improving the crosstalk of multiple factors such as virus toxicity, endothelial cell damage, inflammatory storms, excessive immunity and microthrombosis, and preventing acute respiratory distress syndrome and multi-organ damage
.

Its potential mechanisms of action include: (1) the main active ingredient binds to receptors such as ACE2, 3CLpro, PLpro and TMPRSS2 to block the invasion and replication of the virus; (2) Regulate the secretion of TNF-α, IL-6, IL-1, IL-10 β and other inflammatory factors such as monocytes, macrophages, lymphocytes, etc.
, and chemokines such as CXCL8, CXCL10, CCL2, IP-10, etc.
, to maintain the body's immune and inflammatory balance; (3) Improve IL-6, D-dimer, CRP and other indicators to achieve multi-organ protection, as shown in Figure 2
.

Figure 2.
The principle of action of "three drugs and three parties" in the treatment of COVID-19

Just as the so-called "pandemic comes out of the good cure", the clinical practice of fighting COVID-19 has spawned "three medicines and three parties", which has also enabled China to give full play to the advantages of the combination of traditional Chinese medicine and Western medicine, and greatly improved the cure rate
of patients.
This paper comprehensively introduces the research progress of "three drugs and three parties" in the clinical treatment of COVID-19, and systematically sorts out its potential mechanism of action, aiming to provide a theoretical basis and reference
for understanding the positive role of "three drugs and three parties" in the treatment of COVID-19.

For more details, please visit the journal's official website to read the original article
.
[Click on the link below or read the original article]