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Recently, the team led by Professor Jun Kunisawa of the National Institute of Biomedical Innovation, Health and Nutrition in Japan found that the intestinal bacteria Bw (Blautia wexlerae) was inversely associated with obesity and type 2 diabetes in the population cohort
The data shows that globally, obesity rates have tripled over the past 40 years, with the number of people currently overweight (BMI≥25) and obese (BMI≥30) exceeding 2 billion
The researchers first tested the gut microbiota of 217 adult subjects in a population cohort study and combined BMI and diabetes prevalence to assess the relationship
The researchers recruited another 195 participants from different regions as a validation cohort to examine the relationship between Blautia and obesity, confirming a decline
To identify effective metabolites for Bw bacteria to control obesity and diabetes, the researchers conducted a pathway analysis of Bw bacteria metabolism and found that Bw bacteria's amino acid metabolism and carbohydrate metabolism are unique compared to other intestinal core enterobacteria
However, the researchers noticed that the concentration of propionic acid and butyric acid in the intestine of mice also increased after oral administration of Bw bacteria, and Bw bacteria did not directly produce propionic acid and butyric acid, suggesting that Bw bacteria promoted the proliferation
In summary, the study combined population cohorts, animal experiments, and cell experiments to screen and identify a new probiotic, Bw bacteria, that is negatively correlated with obesity and type 2 diabetes
(Source: BioValley)
China Food News (2022-09-14 03 edition)
(Editor-in-charge: Han Songyan)