The Production Process of (12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]

The production process of (12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]benzoxazepine is a complex and multi-step process that involves various chemical reactions and purification steps.
The following is a detailed overview of the production process:

1. Synthesis of N-phenylpropargylamine: The synthesis of N-phenylpropargylamine, a key intermediate for the production of (12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]benzoxazepine, involves the reaction of phenylpropanamine with hydrogen in the presence of a platinum catalyst.
   
2. Grignard reaction: The N-phenylpropargylamine is then treated with magnesium metal to form a Grignard reagent, which is then treated with a halogenating agent such as chlorine to introduce the halogen into the molecule.
   
3. Acidic hydrolysis: The resulting compound is then hydrolyzed with an acid, such as hydrochloric acid, to produce the corresponding carboxylic acid.
   
4. Alkylation: The carboxylic acid is then treated with a reactive alkylating agent, such as a primary or secondary alkyl halide, to introduce the alkyl group into the molecule.
   
5. Hydrogenation: The resulting compound is then hydrogenated to reduce the amount of double bonds and to remove any unwanted functional groups.
   
6. Deprotection: The last step in the synthesis of (12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]benzoxazepine is the deprotection of the N-phenylpropargylamine group, which is accomplished by treating the compound with an acid or a base.
   

The purification of (12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]benzoxazepine is typically done by column chromatography using a suitable stationary phase such as silica gel or alumina.
The use of high-performance liquid chromatography (HPLC) can also be used for purification, as well as to determine the purity of the synthesized compound.

In conclusion, the production process of (12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]benzoxazepine is a complex and multi-step process that involves various chemical reactions and purification steps.
The key intermediate N-phenylpropargylamine is synthesized by Grignard reaction, followed by halogenation, alkylation, hydrogenation, and deprotection.
The final product is then purified by column chromatography or HPLC.