The Production Process of 2,7-DibroMo-9,9-difluoro-9H-fluorene

The production process of 2,7-dibromo-9,9-difluoro-9H-fluorene involves a series of chemical reactions that convert starting materials into the desired product.
The following is a detailed overview of the production process of this compound in the chemical industry.

Step 1: Preparation of 2,7-dibromo-9H-fluorene
The production of 2,7-dibromo-9H-fluorene involves several steps, starting with the preparation of 2,7-dibromo-9H-fluorene.
This compound can be synthesized using various methods, including the Electrophilic Fluoration of 2,3-Dibromopropene (EBF) method and the Nucleophilic Fluoration of 2,3-Dibromopropene (NFD) method.
The EBF method involves the reaction of 2,3-dibromopropene with bromine in the presence of a Lewis acid catalyst, while the NFD method involves the reaction of 2,3-dibromopropene with fluorine in the presence of a Lewis base catalyst.

Step 2: Bromination of 2,7-dibromo-9H-fluorene
After the preparation of 2,7-dibromo-9H-fluorene, the next step is to introduce two more bromine atoms to the molecule.
This can be achieved using either the Sandmeyer reaction or the Compound 19 reaction.
The Sandmeyer reaction involves the reaction of 2,7-dibromo-9H-fluorene with sodium hydrogen sulfite and sodium hydroxide in the presence of a Lewis acid catalyst, while the Compound 19 reaction involves the reaction of 2,7-dibromo-9H-fluorene with sodium hydride in the presence of a polar protic solvent.

Step 3: Introduction of fluorine atoms
The final step in the production of 2,7-dibromo-9,9-difluoro-9H-fluorene is the introduction of two fluorine atoms to the molecule.
This can be achieved using the Nucleophilic Fluoration of 2,7-dibromo-9H-fluorene (NFD) method, which involves the reaction of 2,7-dibromo-9H-fluorene with fluorine in the presence of a Lewis base catalyst.

Overall, the production process of 2,7-dibromo-9,9-difluoro-9H-fluorene involves a series of chemical reactions that convert starting materials into the desired product.
While the exact production method may vary depending on the manufacturer, the steps involved in the production process are generally similar.
The use of highly reactive and toxic reagents, such as bromine and fluorine, requires careful handling and safety measures to prevent accidents and ensure the health and safety of workers.
Additionally, the production of 2,7-dibromo-9,9-difluoro-9H-fluorene often requires a high degree of purity and accuracy, which may be achieved through the use of advanced purification and characterization techniques.