The Production Process of (2-Chloro-pyrimidin-4-ylmethyl)-ethyl-amine

The production process of (2-chloro-pyrimidin-4-ylmethyl)-ethyl-amine involves several steps, each of which requires careful control and attention to detail to ensure the quality of the final product.
The following is a detailed explanation of the production process of this compound.

Step 1: Preparation of the starting materials
The first step in the production of (2-chloro-pyrimidin-4-ylmethyl)-ethyl-amine is the preparation of the starting materials.
These materials are 2-chloropyrimidine and methylamine.
The 2-chloropyrimidine is synthesized by a series of chemical reactions involving the nucleophilic substitution of chlorine for one of the hydrogen atoms in pyridine.
The methylamine is synthesized by the Hydrogenation of Methyl iodide.

Step 2: Coupling of the starting materials
The next step is the coupling of the starting materials to form (2-chloro-pyrimidin-4-ylmethyl)-amine.
This is typically done by heating the 2-chloropyrimidine and methylamine in the presence of a polar protic solvent, such as water or methanol.
The reaction is typically carried out under conditions where the temperature is gradually increased over a period of several hours.
The use of a solvent helps to increase the reaction rate and to enhance the solubility of the reactants.

Step 3: Nitration of the product
The (2-chloro-pyrimidin-4-ylmethyl)-amine obtained from the previous step is then treated with nitric acid to form (2-chloro-pyrimidin-4-ylmethyl)-ethyl-amine.
This step is typically carried out by adding nitric acid to a solution of (2-chloro-pyrimidin-4-ylmethyl)-amine in water, and then allowing the mixture to sit for a period of time, typically several hours, to allow the nitration reaction to proceed.
The reaction is typically carried out at a moderate temperature and the mixture is then filtered to remove any insoluble solids that may have formed.

Step 4: Hydrolysis of the nitro compound
The next step is the hydrolysis of the nitro compound (2-chloro-pyrimidin-4-ylmethyl)-ethyl-amine, which is done to remove the nitro group.
This is typically done by treating the nitro compound with water and a base such as sodium hydroxide.
The reaction is typically carried out at a moderate temperature, and the mixture is then filtered to remove any insoluble solids that may have formed.

Step 5: Purification of the product
The final step in the production process of (2-chloro-pyrimidin-4-ylmethyl)-ethyl-amine is the purification of the product.
This is typically done by crystallization, which allows the separation of the desired product from any impurities that may have formed during the previous steps.
The crystals are then dried and weighed to determine the yield of the product.

In conclusion, the production process of (2-chloro-pyrimidin-4-ylmethyl)-ethyl-amine involves several steps, including the preparation of the starting materials, the coupling of the starting materials, the nitration of the product, the hydrolysis of the nitro compound, and the purification of the product.
The quality of the final product depends on the accuracy and precision of each step in the process, and so it is important to carefully control and monitor each step to ensure the desired yield and purity of the final product.