echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Medical News > Medical World News > The Production Process of 4-Chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile

    The Production Process of 4-Chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile

    • Last Update: 2023-05-14
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit

    The Production Process of 4-Chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile: An Overview of the Chemical Industry

    In the world of organic chemistry, 4-chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile is a compound that has gained significant attention due to its unique chemical properties and potential applications.
    The process of producing this compound involves a series of chemical reactions that require careful planning and execution.
    In this article, we will explore the production process of 4-chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile, highlighting the various steps involved in the chemical industry.

    Step 1: Preparation of the Starting Materials

    The production of 4-chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile begins with the preparation of the starting materials.
    In this case, the starting materials are 4-chloro-6-fluoropyrimidine and 1,7-naphthyridine-3-one.
    These compounds are synthesized separately through different chemical reactions and are then combined to form the final product.
    The preparation of these starting materials requires the use of specialized equipment and chemical reagents, and the process must be carried out under strict conditions to ensure purity and consistency.

    Step 2: Diazotization of 1,7-Naphthyridine-3-one

    The next step in the production process is the diazotization of 1,7-naphthyridine-3-one.
    This step involves the addition of nitrating reagents to the starting material under controlled conditions to introduce nitrogen atoms into the molecule.
    The use of diazotizing agents such as sodium nitrite and hydrochloric acid results in the formation of an intermediate compound that contains nitrogen.

    Step 3: Hydrazonization of 4-chloro-6-fluoropyrimidine

    In the third step, 4-chloro-6-fluoropyrimidine is subjected to hydrazonization.
    This involves the reaction of the starting material with a hydrazone derivative of 1,7-naphthyridine-3-one, which has been synthesized in the previous step.
    The hydrazonization reaction is carried out in the presence of a condensing agent such as pyridine, and the resulting product is a double hydrazone derivative that contains both nitrogen and sulfur atoms.

    Step 4: Formation of the Final Product

    The final step in the production process of 4-chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile involves the condensation of the intermediate double hydrazone derivative with malononitrile under the presence of a catalyst such as triethylamine.
    This reaction results in the formation of the final product, which is a carbonitrile derivative of 1,7-naphthyridine.

    Quality Control Measures

    The production of 4-chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile requires strict quality control measures to ensure the purity and consistency of the final product.
    This involves the testing of the product for various physical and chemical properties, including its melting point, boiling point, and chemical reactivity.
    These tests are carried out using specialized equipment and techniques to ensure that the product meets the required standards for use in various applications.

    Applications of 4-chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile

    The applications of 4-chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile are vast and varied, reflecting its

    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.