The Production Process of N-(tert-Butyl)-3,6,7-trichloroquinoxalin-2-amine

The production of N-(tert-Butyl)-3,6,7-trichloroquinoxalin-2-amine, also known as tert-Butyl-2-(3,6,7-trichloro-2H-quinoxalin-2-ylamino)acetate, is a highly complex process that involves multiple steps and various reagents.
The molecule is a synthetic precursor to various pharmaceutical compounds, and its production has been extensively researched in the chemical industry.

The production process of tert-Butyl-2-(3,6,7-trichloro-2H-quinoxalin-2-ylamino)acetate can be divided into several stages, including the preparation of the starting materials, the actual synthesis of the molecule, and the purification and isolation of the final product.

1. Preparation of Starting Materials

The production of tert-Butyl-2-(3,6,7-trichloro-2H-quinoxalin-2-ylamino)acetate begins with the preparation of the starting materials, which include 3,6,7-trichloro-2H-quinoxalin-2-one and N-(tert-butyl)acetamide.

The synthesis of 3,6,7-trichloro-2H-quinoxalin-2-one, also known as 3,6,7-trichloro-2H-quinazoline-2,4-dione, typically involves the reaction of 2,4-dichlorophenylamine with malonic acid.
The resulting compound is then treated with sodium hydroxide to produce the quinoxaline-2,4-dione.

N-(tert-butyl)acetamide, on the other hand, can be synthesized by the reaction of acetyl chloride with tert-butylamine.

2. Synthesis of Tert-Butyl-2-(3,6,7-trichloro-2H-quinoxalin-2-ylamino)acetate

Once both starting materials are prepared, the synthesis of tert-Butyl-2-(3,6,7-trichloro-2H-quinoxalin-2-ylamino)acetate can begin.
The synthesis typically involves several steps, including the reaction of N-(tert-butyl)acetamide with 3,6,7-trichloro-2H-quinoxalin-2-one in the presence of a solvent such as dichloromethane.

The reaction typically involves the use of a strong acid catalyst, such as hydrochloric acid, to promote the reaction.
The resulting product is then treated with a base, such as sodium carbonate, to remove any remaining acid.

The resulting product is typically purified by chromatography, either by column chromatography or by high-performance liquid chromatography (HPLC).
This step is necessary to remove any impurities that may have been introduced during the synthesis process.

3. Purification and Isolation of the Final Product

The final step in the production of tert-Butyl-2-(3,6,7-trichloro-2H-quinoxalin-2-ylamino)acetate is the purification and isolation of the final product.
This typically involves the use of a chromatography method, as mentioned earlier, to remove any impurities that may have been introduced during the synthesis process.

The final product is then isolated by collecting the appropriate fractions from the chromatography column.
The product can be further purified by recrystallization, which involves dissolving the product in a suitable solvent and then allowing it to crystallize out of solution.

4. Safety Measures

The production of