The qin shengying team of Shanghai Jiaotong University revealed the molecular mechanisms related to the initiation of metabolic syndrome by antipsychotic drugs and their new targets for prevention

Recently, the Qin Shengying team of the Bio-X Research Institute of Shanghai Jiao Tong University published a research paper on Multi-omics analysis identifies rare variation in leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to antipsychotics-induced metabolic syndromes

Antipsychotic drug treatment is the main clinical treatment of schizophrenia and many other psychiatric diseases, but about 40% of patients will have the adverse reaction of drug-induced metabolic syndrome after receiving antipsychotic treatment, which seriously affects the quality of life of patients with schizophrenia and leads to a decrease in medication compliance, bringing a huge medical burden

This paper focuses on the subpopulation of patients with metabolic syndrome after treatment with schizophrenia antipsychotic drugs, and uses high-throughput multi-omics techniques such as whole genome association analysis, whole exome sequencing analysis, whole genome methylation analysis and transcriptome sequencing to find that a number of common and rare genetic variants are related to the occurrence of drug-induced metabolic syndrome

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