The Ras gene mutation halts cancer cell metastasis.

Metastasis is the process by which cancer cells leave the primary tumor and spread to other parts of the body, causing more than 90% of cancer deaths.
therefore, there is a significant need to improve treatment options for metastatic cancer patients.
in order for cancer cells to metastasize, the cell's death path needs to be cut off, while changing defects in cell energy production.
researchers specifically studied the Ras mutation.
ras gene is a primary cancer gene, which means it is a gene that exists in normal, non-cancerous cells.
when Ras DNA changes specifically or mutates, this mutation can lead to the development of cancer.
and Ras mutations are most common in lung, colon and pancreatic cancers, and Ras is the most common, mutant primary cancer gene observed in all human cancers. "We found that for cancer cells with Ras mutations, two different proteins can be regulated to shut down the path of cell death: SGK-1 and PHLPP1," Schaefer said.

increased energy production improved the survival of these cells.
, Ras also causes a decrease in the amount of the protein PHLPP1, which reduces the ability of PHLPP1 to cause cell death.
in general, these two changes in cells (SGK-1 activation and phLPP1 reduction) promote the survival of metastatic cancer cells.
" although more research is needed, the results suggest that an effective strategy to eliminate cancer cell metastasis using Ras mutations may simultaneously inhibit SGK-1 activity, block energy production, and restore phLPP1 activity, leading to cell death. "We are currently expanding our research to better understand whether SGK-1 and PHLPP1 play an important role in controlling cancer cells at different stages of the metastasis process,"
.
for example, when cells leave primary tumors for the first time and when they move to a place where they begin to proliferate again," Schaefer said, "We also assessed which cancers SGK-1 and/or PHLPP1 are most important for regulating the survival of cancer cells."
current research is done in breast epithelial cells and lung cancer cells, it is important to understand that these molecular demonstration films, as we assume, also involve a variety of different cancers.
" Source: Decoding Medicine.