The ratio of triglyceride to HDL-C can be used to evaluate insulin resistance and diabetes in the elderly

According to a recent study, the ratio of triglyceride to high-density lipoprotein (HDL) cholesterol can be used as a better evaluation index of insulin resistance and diabetes in the middle-aged and elderly in China compared with other blood lipid parameters Diaozhu Lin, a researcher from Sun Yat sen University in Guangzhou, said that according to the recent lipid management recommendations, low-density lipoprotein (LDL) cholesterol control is the main treatment target for diabetics with dyslipidemia There is evidence that the level of blood lipid and the prevalence of dyslipidemia in diabetic patients depend to a large extent on the region, nationality, economic level and health care level Other lipid metabolism indexes (such as the ratio of combined lipids) can better reflect the overall interaction between lipid and lipoprotein components It is not clear whether other lipoprotein parameters besides LDL cholesterol can provide more clinical information about diabetes related insulin resistance and proper blood glucose control In the cross-sectional study, Lin and colleagues analyzed the data of 9764 adult participants (mean age, 56 years old) from Guangzhou in the action study conducted from June to November 2011 (http:// Participants completed life style and history questionnaire and provided fasting blood samples to measure serum insulin, fasting blood glucose, triglyceride, total cholesterol, HDL cholesterol, LDL cholesterol and creatinine Participants also completed two hours oral glucose tolerance test (http:// The researchers calculated HbA1c, triglyceride glycemic index, estimated glomerular filtration rate, insulin resistance index of steady-state model, and non-high-density lipoprotein cholesterol In the cohort, 1630 (16.7%) participants were diagnosed with diabetes; 2442 (25%) participants were considered to have insulin resistance After adjusting for factors such as age, gender, BMI, smoking, drinking, physical activity, systolic blood pressure, diabetes, dyslipidemia and cardiovascular disease, the researchers found that the incidence rate of insulin resistance and diabetes increased with the increase of triglyceride, non HDL cholesterol, non HDL cholesterol /HDL cholesterol ratio and triglyceride /HDL cholesterol ratio, and increased with the increase of HDL cholesterol Decreased (P < 0.001) In logistic regression analysis, the researchers found that the possibility of insulin resistance increased with the increase of triglyceride, total cholesterol, LDL cholesterol, non HDL cholesterol, non HDL cholesterol / HDL cholesterol ratio and triglyceride / HDL ratio; however, the researchers did not observe the correlation between total cholesterol and LDL cholesterol and diabetes The researchers stressed that when compared with other lipid parameters, the triglyceride / HDL cholesterol ratio was closely related to insulin resistance and diabetes in all linear regression models