The research application of stem cells in bone cancer treatment

In recent years, more and more research has found stem cells to be a useful tool for treating cancer.
stem cells have been used to renew the immune system for patients with radiotherapy or chemotherapy, and have been modified to carry therapeutic agents to target tumor sites.
scientists have made progress in the field of stem cell therapy for metastatic bone cancer.
recently, News-Medical has conducted an expert interpretation of the field.
is a kind of bone malignant tumor disease, the incidence rate of about 0.2% of the systemic malignant tumor, clinical treatment is mainly surgery, combined with other treatment methods.
, why can stem cells be used to treat bone cancer, and how do scientists use stem cells to treat bone cancer? How do I use stem cells in cancer medicine? Stem cells are cells with two different special functions -- both infinite self-renewal and the ability to differentiate into multiple types of tissue cells.
, scientists have identified three types of stem cells.
include embryonic stem cells, adult stem cells and induced erypotent stem cells.
in patients with bone marrow damage or compromised immune systems, stem cells derived from bone marrow or blood can be transplanted to restore normal bone marrow hematopoietic function.
technique is widely used to treat bone cancer patients with bone marrow damage or decreased immunity.
recent years, a variety of stem cell-based cancer treatment strategies have emerged.
, for example, in cancer patients, the function of T cells, which play a key role in adaptive immunity, changes, which promotes cancer cells to evade T-cell-mediated removal.
T-cells produced by induced erythrogen stem cells can specifically identify and destroy cancer cells, a potential stem cell therapy that improves cancer-related prognostication.
For example, Japan first experimented with treating cancer with iPS cells, and they ended up transplanting immune cells , natural killer T-cells (NKT cells), cultured from induced erythnic stem cells (iPS cells).
strategy is stem cell-based gene therapy.
in cancer-related gene therapy, the unique characteristics of stem cell migration to the damaged site are utilized, where stem cells are used as vectors that can be specifically transported and delivered to the tumor site by therapeutic drugs or viral vectors.
in particular, are best suited for delivering therapeutic agents to tumor sites.
cytokines secreted by tumors promote the migration process by stimulating interstumined stem cells to produce more cytokines, which are cytokines responsible for directed cell migration.
in animal studies, researchers used interstumogenic stem cells to deliver cancer drugs to mice, reducing the drug's damage to non-tumor tissue.
stem cells in bone cancer treatment research applications, stem cells have been widely used in bone cancer treatment research.
, for example, interstate stem cell transplantation has become a promising treatment for patients with bone diseases, including bone cancer.
In bones, metastatic cancer cells induce bone-breaking cell production, and stem cell-based targeted delivery mechanisms are used to transport drugs that inhibit bone-breaking cell production, a strategy that has become an important option for treating metastatic bone cancer.
Recently, researchers have been developing a combination of drugs that can deliver simultaneous targeting of bone cancer and its micro-environment, using mRNA-based protein expression, and interstitrinated stem cells have been loaded with three different therapeutic drugs: one for nesting stem cells specifically to the transfer site; One used to effectively destroy cancer cells; One is a cytokine complex that inhibits the formation of bone-breaking cells.
these engineered interstitine stem cells have been shown to be effective and specifically targeted for metastatic bone cancer, and can effectively damage cancer cells without compromising bone integrity.
bone cancer, stem cells have also been used and studied in other orthopaedic diseases.
2009, the European-approved stem cell drug Chondrocelect was launched for treatment of cartilage defects in the knee.
In 2012, South Korea approved the interstitial stem cell drug Cartistem for the treatment of degenerative arthritis and knee cartilage injuries, and in 2016, the United States approved the listing of the stem cell drug Maci for the treatment of knee cartilage injuries.
, several new stem cell drug clinical trials for osteoarthritis have been approved this year.
common treatments for small bone cancer include surgical therapy, chemotherapy and radiotherapy, but most of them have adverse side effects.
, drugs used to prevent bone cancer-related mergers often do not have effective anti-tumor properties.
in cell-based targeted therapies, genetically modified cells are only used to deliver single-type drugs, which is not a very safe technique.
, mRNA-based engineered interstuming stem cells have many advantages.
, for example, it is a simple and safe method that does not require genetic engineering.
process allows for rapid and short-lived expression of multiple proteins at the same time, which can promote cancer cell death with minimal side effects.
, I believe stem cell therapy will bring good news to more bone cancer patients as scientists study more and more deeply! References: . . . Nguyen ST. 2015. Stem cell technology and engineering for cancer treatment. Biomedical Research and Therapy. Morishita T. 2006. Tissue engineering approach to the treatment of bone tumors: three cases of cultured bone grafts derived from patients' mesenchymal stem cells. Artificial Organs. Segaliny AI. 2019. combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells. EBioMedicine.#bb0145