echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > The research team of Professor Song Huaidong of the Ninth Affiliated Hospital found a new pathogenic mechanism and potential therapeutic target of "Hashimoto's thyroiditis"

    The research team of Professor Song Huaidong of the Ninth Affiliated Hospital found a new pathogenic mechanism and potential therapeutic target of "Hashimoto's thyroiditis"

    • Last Update: 2022-03-08
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    At 5:00 EST on February 9, 2022, "Nature Communications", a sub-journal of "Nature", published the research paper "Lymphocyte Infiltration and Thyrocyte Destruction is Driven by Stromal" by Professor Song Huaidong's research team from the Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine and Immune Cell Components in Hashimoto's Thyroiditis"
    .


    ( https:// ) This study revealed the ectopic infiltration of lymphocytes into thyroid tissue in patients with Hashimoto's thyroiditis, which has long plagued people, leading to the destruction of thyroid follicular cells.


    Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease (AITD), with a prevalence of more than 10% in the female population
    .


    Typical HT is characterized by massive lymphocytic infiltration of thyroid tissue, formation of ectopic lymphoid tissue, and destruction of thyroid follicular cells, and the presence of thyroid peroxidase antibody (TPOAb) and thyroglobulin Antibodies (Thyroglobulin antibody, TGAb), but so far, the mechanism leading to massive lymphocytic infiltration and thyroid cell destruction in the thyroid tissue of HT patients is poorly understood


    Figure 1.
    Multicolor immunofluorescence staining of thyroid tissue sections from patients with Hashimoto's thyroiditis showing the distribution of CCL21+ stromal cells

    The pathogenesis of HT is unclear and there is a lack of treatment for the cause
    .


    To further explore the pathogenesis of HT, Song Huaidong's group identified multiple subpopulations of thyroid tissue stromal cells in HT patients by single-cell sequencing, among which CCL21+ myofibroblasts and CCL21+ positive fibroblasts both highly expressed CCL19 and CCL21


    Figure 2.
    There are specific inflammatory macrophages and inflammatory dendritic cell subsets with high IL-1β expression in the thyroid tissue of patients with Hashimoto's thyroiditis

    In addition, the study also found that there are inflammatory macrophages and dendritic cell subsets specifically in the thyroid tissue of patients with Hashimoto's thyroiditis, and they all significantly overexpress a number of inflammation-related genes.
    The expression increased most significantly
    .


    Previous literature has shown that IL-1β can promote CD40L-mediated dendritic cell activation, promote the activation and proliferation of CD4+ T cells stimulated by antigens, promote Th17 cell differentiation, and induce ectopic high expression of FAS in thyroid follicular cells, thereby making Apoptotic destruction of thyroid follicular cells


    This study suggests that CCL19/CCL21 may play an important role in the infiltration of immune cells in thyroid tissue and the formation of tertiary lymphoid tissue during the occurrence of HT, while specific inflammatory macrophages and dendritic cells infiltrated into thyroid tissue A subpopulation that may contribute to the destruction of thyroid follicles by secreting IL-1β
    .


    Therefore, targeted blocking of the interaction between CCL19/CCL21 and CCR7 is expected to block thyroid immune cell infiltration, thereby reducing thyroid follicle destruction and delaying the onset of hypothyroidism


    In the past ten years, only 8 papers have been published in the international famous journal CNS and its sub-journals in the field of global autoimmune thyroid disease research
    .


    This is the second research paper on the pathogenesis of autoimmune thyroid disease published by Professor Song Huaidong's team in the CNS sub-journal after a lapse of 10 years.


    Song Huaidong is an academic leader, doctoral tutor, second-level professor, chief physician, researcher, and second-instance expert of the National Foundation of China, Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine
    .


    Top Ten Outstanding Young People in Shanghai, Special Allowance Expert of the State Council, National Talent of "New Century Talent Project" of Ministry of Personnel, "New Century Talent" of Ministry of Education, Shanghai Excellent Discipline Leader, and Shanghai "Leading Talent"


    Dong Mei
    Affiliated Ninth Hospital
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.