The research team of sun Zhoutong enzyme molecular engineering and industrial biocatalysis of Tianjin Institute of technology has made progress in the research of biocatalyst carboxylic acid reductase

Carboxylic acid reductase (car, EC 1.2.1.30 and EC 1.2.1.31) is a kind of multifunctional enzyme, which is widely distributed in bacteria, fungi and some plants It can efficiently catalyze the chemical reaction from carboxylic acid to aldehyde It has important research significance and broad market application prospect However, there is lack of analysis and comment on the current situation and progress of this enzyme Recently, the research team of enzyme molecular engineering and industrial biocatalysis led by sun Zhoutong, researcher of Tianjin Institute of industrial biotechnology, Chinese Academy of Sciences, summarized the latest research progress of carboxylic acid reductase and its application in biological level catalytic reaction from the perspectives of system generation, catalytic mechanism and industrial application The reduction of carboxylic acids to aldehydes by traditional chemical methods requires not only precious metals as catalysts, but also extreme reaction conditions, poor tolerance to adjacent functional groups and side reactions In contrast, the "biocatalyst" carboxylic acid reductase as the core of the biosynthesis method, not only has mild reaction conditions, broad substrate spectrum and strong pertinence, can specifically identify carboxylic acid groups, but also can solve the environmental pressure and energy problems caused by the chemical synthesis method, significantly reducing the resource and energy consumption in the production process In addition, carboxylic acid reductase can also form a cascade reaction with alcohol dehydrogenase, transaminase and imine reductase to generate downstream compounds with high added value, such as alcohols, ammonia and imines, which can be used in the fields of additives, clean energy, fine chemicals and biomedicine At the same time, the industrial application prospect of using directed evolution technology to modify carboxylic acid reductase is also prospected Source of application of carboxylic acid reductase in biological cascade reaction: green chemistry this review has been published in green chemistry, a well-known journal in the field of chemistry, supported by the "Hundred Talents Program" of the Chinese Academy of Sciences and the program of selecting the best overseas students in Tianjin Qu gobos of Tianjin Institute of industrial biology is the first author of the paper, and sun Zhoutong is the corresponding author Paper link: http://pubs.rsc.org/en/content/article landing/2018/gc/c7gc03046k ා! Divabstract communication author profile: sun Zhoutong researcher: http://sourcedb.tib.cas.cn/cn/expert/rckyjy/201609/t20160918_.html sun Zhoutong researcher