The researchers found a mechanism for the delivery of nanodrive vectors

the Chinese Academy of Sciences Shanghai Pharmaceutical Institute Ganyong team and the National Nanoscience Center Shi Xinghua team, in-depth analysis of the nano-drug carrier's performance on overcoming multiple physiological barriers. The results were published online in
journal.
drug vectors need to overcome multiple physiological barriers in the organism before reaching the target cells. To maximize efficacy, designing and preparing delivery vectors that overcome multiple physiological barriers and have efficient cell ingestion is an important challenge for nanodrives to move from laboratory to clinical application.
It is understood that Gan Yong and Shi Xinghua discovered in the early stages that the unique "rotation-jumping" movement of rod-like particles can promote its diffusion in mucus, and put forward an obstacle to considering the effect of particle adhesion - diffusion theory model. At the same time, the two sides also found common physiological factors restricting the oral delivery of nano-vectors and tumor delivery drugs: biological gels with mesh structure (such as mucus and tumor intercellular interstitials) played an important role in blocking the arrival of drug vectors on target cells.
In the latest study, using microflow control technology, the researchers designed and prepared a nanopharmaceutical vector with adjustable stiffness, and found that the vector with moderate stiffness had the highest diffusion coefficient in the biogel, with optimal cell intake and drug delivery capacity. (Source: Huang Xin, China Science Daily)