The risk of Alzheimer's disease is reduced by nearly 40% by influenza and pneumonia vaccines or as a preventable disease.

This week, the Alzheimer's Association International Conference (Alzheimer's International Conference, AAIC-2020) opened.
AAIC is one of the largest and most influential international conferences in the world focused on the scientific study of mental disorders.
because of the COVID-19 pandemic, this year's AAIC held online, in the COVID-19 pandemic moment, people are very concerned about the development and efficacy of vaccines.
two new studies published in AAIC 2020 suggest that vaccines not only prevent infectious diseases, they may also reduce people's risk of developing Alzheimer's disease (AD).
study, vaccination against pneumonia reduced the risk of AD in some older adults by nearly 40 percent! The first study on influenza and pneumococcal vaccines and reduced risk of Alzheimer's disease came from a team at the University of Texas Health Science Center in Houston.
they analyzed a database of 9,066 U.S. patient health cases to explore the relationship between seasonal flu vaccination and AD risk.
results of the trial showed a 17% reduction in the incidence of AD in people vaccinated against influenza (OR?0.83, p?lt;0.0001).
, the number of flu vaccinations also had a significant impact on the incidence of AD, with a further 13% reduction in the risk of AD in people who were vaccinated multiple times.
researchers also found that getting the flu vaccine for the first time at a younger age had a greater impact on the risk of AD disease.
example, an elderly person who was first vaccinated against influenza at age 60 may benefit more than an elderly person who was first vaccinated at age 75.
second study came from a team at Duke University.
they looked at the relationship between pneumococcal vaccination and AD risk in 5,146 people over the age of 65.
study found that older adults who had been vaccinated against pneumococcal between the ages of 65 and 75 had a 30 percent lower risk of AD disease (OR?0.70, p?lt;0.04).
researchers know that some genetic variants increase the risk of AD disease, such as specific mutations in genes called TOMM40, which increase the permeability of the blood-brain barrier and make the brain more susceptible to infection.
this is a known AD risk factor.
in people who did not carry this risk factor, the risk of developing AD in older people vaccinated against pneumococcal disease was reduced by nearly 40% (OR?0.62, p?lt;0.04).
the potential link between pathogen infection and AD incidence, both studies were related studies that did not determine whether there was a causal link between influenza or pneumococcal vaccine and a reduced risk of AD disease.
researchers are also conducting further research to explore the biological mechanisms by which vaccination affects the risk of AD disease.
, however, there is some speculation about how vaccination reduces the risk of AD disease.
traditional theory suggests that AD is caused by the degradation and death of neurons in the brain due to the deposition of amyloid proteins in the brain.
however, in recent years, several treatments for amyloid have failed in clinical trials, calling into question the amyloid hypothesis.
, AD research and development is now more diverse, and researchers are turning their attention to inflammation of the brain and the possible effects of viral and bacterial infections on the brain.
we generally believe that the brain is protected by a blood-brain barrier, and that bacteria and viruses cannot cross the blood-brain barrier into the brain and infect brain cells.
, however, scientific studies have found that some viruses can cross the blood-brain barrier, such as the H5N1 flu virus, which can enter the central nervous system, triggering nerve inflammation and neurodegeneration.
in animal models, the H1N1 flu virus does not enter the central nervous system, but it activates microglia in the brain, triggering an inflammatory response in the brain.
, infections with viruses or other pathogens can lead, directly or indirectly, to damage nerve cells in the brain.
have also found a correlation between viral or bacterial infections and the risk of developing Alzheimer's disease.
vaccination may help improve the body's immunity to viruses and bacteria, thereby reducing the brain's risk of being affected by pathogens and the knock-on effects that may increase the risk of AD disease.
is critical to preventing AD disease at this time, we do not have a cure for AD.
Dr. Maria Carrillo, chief scientific officer of the Alzheimer's Association, said in an interview that if getting a flu or pneumonia vaccine reduces the risk of AD, it's an important message for the general public.
we still need more research to understand the link between the two," Dr. Carrillo said. Or is it similar to controlling your weight and sugar intake, exercising more, and so on, as part of our comprehensive strategy to reduce AD risk? We will strive to ensure that the public is aware of this information.
highlight of the study published last year in AAIC was that healthy lifestyle habits may offset the risk of dementia.
, published this year, suggest that we should perhaps include regular vaccinations in healthy living habits.
: FLU, PNEUMONIAS TIED TO LOWER RISK OF DEMENTIA. Retrieved July 28, 2020, from Flu Shot And Pneumonia May Vaccine Reduce Miller's Risk, Research Research Shows. Retrieved July 28, 2020, from Flu and pneumonia shots may lower risk for Alzheimer's, studies find. Retrieved July 28, 2020, from Flu and Pneumonia Vaccines Linked to Reduced Risk of Alzheimer's. Retrieved July 28, 2020, from ▽ attention to the Public No.