The RNA anti-chain exchange guided by the congener recombinant protein Rad52 repairs the damaged DNA.

Researchers at Dresell University and Georgia Institute of Technology in the United States have found that the Rad52 protein plays a crucial role in RNA-dependent DNA repair.
study, published in molecular Cell on August 8, revealed the important role of the congener recombinant protein Rad52.
the results could also help cancer treatment identify new targets.
chemotherapy and radiotherapy can lead to broken DNA strands, one of the worst cases of DNA damage.
process of recombination, which exchanges genetic information between two DNA molecules, plays a crucial role in DNA repair, but specific genetic mutations can disrupt gene stability.
, mutations in the tumor suppressor gene BRCA2 can lead to the most serious breast and ovarian cancers.
Alexander Mazin of the University of Texas School of Medicine and Assistant Professor Francesca Storici of the Georgia Institute of Technology conducted the study to figure out the proteins and mechanisms that promote DNA repair.
2014, Storici and Mazin discovered that RNA can act as a template for repairing double-stranded fractures in DNA in budding yeast, and Rad52 is one of the same-origin recombinant paths that play an important role in this process.
evidence suggests that RNA can be used to repair DNA templates, and rad52 proteins are involved in this process," said Mazin, a RNA expert.
't know how Rad52 is involved in this process.
"In this study, the team found an unusually important role for Rad52: it promotes "anti-chain exchange" between double-stranded DNA and RNA, which means the protein has the ability to bind hemogenetic DNA and RNA molecules together.
RNA can be used as a template for accurate DNA repair.
: The paper shows that Rad52's ability in ethnomic organisms is unique, unlike any other similar protein.
Rad52 uses this anti-chain exchange process of RNA without requiring in-depth processing of damaged DNA ends, suggesting that RNA-based repair may be a mechanism that can repair DNA quickly," Storici said.
researchers hope to determine the role of the Rad52 protein in human cells in future work.
added: "DNA damage is the cause of a variety of degressive diseases, including cancer.
need to understand how cells maintain genetic stability.
discovery helps us better understand complex DNA repair mechanisms.
results provide a new perspective on the multi-layered relationship between RNA, DNA, and gene stability, as well as new therapeutic targets for cancer treatment.
the proliferation of breast cancer cells with BRCA (Breast Cancer Susceptible Gene) defect requires active Rad52.
use small molecule inhibitors to target this protein is a good anti-cancer strategy.
however, the key rad52 activities involved in cancer cell proliferation remain unclear.
Rad52's role in DNA repair may represent this critical protein activity, which can be used as a target for inhibitors to help develop more specific (less toxic) anticancer drugs.
understanding of RNA-guided DNA repair mechanisms could also facilitate the development of new RNA-based genetic engineering methods.
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