The roller coaster is not the middle host of the new crown, or may be a potential natural host

Reporter 24 from Yunnan University was informed that the provincial department jointly built Yunnan biological resources protection and utilization of the national key laboratory Zhang Zhigang team on malay roller coaster is not the middle host of the new coronavirus, but may be similar to the new coronavirus virus potential natural host of the study results, recently published in cell sub-journal "current biology."
On February 2, this year, a team led by researcher Zhang Zhigang reassembled and comprehensively analyzed the viromic data from a successful pulmonary sample of a manicure lung that could not be rescued on March 24, 2019, and found that it carried a crown similar to that of the new coronavirus. The genomic similarity of the virus, named Pangolin-CoV, to the bat coronavirus reported by the New Coronavirus and the Wuhan Virus Shi Zhengli team was 91.02% and 90.55%, respectively.
study found that the kinship between the coronavirus and the new coronavirus is second only to the bat coronavirus, but the s1 functional sequence of the coronavirus and the new coronavirus is highly consistent, involving five key amino acid residues with human ACE2 subjects, while the bat coronavirus has four mutations, suggesting that the coronavirus and the new coronavirus have similar host cell recognition capabilities. The study also found that at the S1/S2 enzyme cut-off point, the new coronavirus contained a similar Furin protein recognition sequence of the MIDDLES coronavirus, while the karst coronavirus, bat coronavirus and SARS coronavirus all lacked this functional substation, indicating that the new coronavirus and the MIDDLE RESPIRATORy syndrome coronavirus have similar host cell invasion mechanisms.
research progress was first reported to the Ministry of Science and Technology on February 15 "New Coronavirus infection of pneumonia outbreak emergency response project", the pre-printed copy was published on February 20 in bioRXiv. On 26 February, nature-news made a quotation. The March 19 issue of Cell's sub-series, The Department of Contemporary Biology, was published under the title "Malay roller coasters may be potential natural hosts of new coronavirus-like viruses", and research data is freely available on relevant platforms.
earlier, researchers at the Wuhan Virus Institute Shi Zhengli reported that the bat coronavirus RaTG13 is about 96% similar to the genome of the new coronavirus, proving that chrysanthemum bats are a potential natural source of the new coronavirus. Zhang Zhigang researchers told Science and Technology Daily that because the genomic similarity between the coronavirus and the new coronavirus did not reach 99% or more of the similarity required by the intermediate host, it proved that the coronavirus and the new coronavirus are not the same virus, but only the new coronavirus;
On February 7 this year, South China Agricultural University held a press conference to announce that they had analyzed the virus genome and found that the isolated strains in panesans were as similar as 99% to the sequence of new coronavirus strains currently infected with humans, and pansails were the "potential intermediate host" of the new coronavirus. Subsequent studies confirmed that the south China Agricultural University report was false positive and released revised data with a similarity of 90.3 per cent, while the
University management team found 92.4 per cent evidence. "Several team studies samples were taken from the same batch of smuggled paraphern armor intercepted by Guangdong Customs in March 2019. The revised data is close to ours. Zhang Zhigang said.
's comprehensive research suggests that mid-chrysanthemum manta rays and Malay roller coasters are just potential natural source hosts, considering a genetic point similar to the new coronavirus and THES coronavirus, which involves viral infections, and may even be the host of other unrecovered natural sources. Whether it's bat coronavirus, latha coronavirus, or other coronavirus that may not have been detected by the natural source host, it's not known what kind of intermediate host evolved and then spread to humans, and it's impossible to determine the intermediate host and natural source host of the new coronavirus.
Zhang Zhigang research team believes that from the current discovery of chrysanthemum head bats, Malay panna ligas two possible source of the host distribution area, south China is only one of the possible potential natural hosts of the middle chrysanthemum head manta ray distribution area, the existing research can not determine the occurrence of the new coronavirus, not to indicate that the new coronavirus originated in China.
"If the two potential natural source hosts, chrysanthemum manta rays and Malay roller coasters, can prove to be the natural source hosts of the new coronavirus, then their current natural distribution areas may be the place where the new coronavirus occurs. And crucially, what is the intermediate host? Where did it happen? Why did it break out in Wuhan? It is also the core of future scientific research. Zhang Zhigang said.
This study also provides the first comprehensive clarification of the relationship between the new coronavirus and the coronavirus, bat coronavirus, SARS coronavirus and the Middle East Respiratory Syndrome coronavirus, and suggests that there are other unknown intermediate hosts of the new coronavirus beyond bats and roller coasters, which provides an important reference for further understanding the source and route of transmission of the virus.
Tracking the future of the new coronavirus, Zhang Zhigang's research team suggested that a comprehensive survey of bats, predators and hoofed animals, rodents and their natural distribution areas with smuggled Malay carnivores could be concentrated, as well as a comprehensive survey of carnivores, hoofed animals, rodents and their natural distribution areas.