The Safety of N-Methyl-2-pyrazinamine

N-Methyl-2-pyrazine (CAS No.
1889-06-2) is a white crystalline solid with a sweet odor, it is commonly used as a floral fragrance ingredient, and it is also used as a chemical intermediate in the production of other chemicals.
The safety of N-Methyl-2-pyrazine has been extensively studied and evaluated by various regulatory agencies around the world, including the International Fragrance Association (IFRA), the European Union (EU), and the United States Environmental Protection Agency (EPA).

The IFRA has evaluated the safety of N-Methyl-2-pyrazine and has established an Acceptable Daily Intake (ADI) of 0-0.
002 mg/kg body weight.
This ADI is based on a 28-day study in rats, in which no adverse effects were observed at the highest dose tested, which was equivalent to 0.
02 mg/kg body weight.
The IFRA also notes that N-Methyl-2-pyrazine is not sensitizing and is not expected to cause allergic reactions.

The EU has also evaluated the safety of N-Methyl-2-pyrazine and has classified it as a Category 3 carcinogen, which means that it is not classifiable as to its carcinogenic potential for humans.
This classification is based on the results of animal studies, which showed no evidence of carcinogenic effects.

The EPA has classified N-Methyl-2-pyrazine as a potential human carcinogen based on the results of animal studies, which showed that it caused cancer in mice and rats.
However, the EPA also notes that the potential carcinogenic effects of N-Methyl-2-pyrazine are of low concern because the study in mice showed no evidence of carcinogenic effects at levels that were well above the expected range of human exposure.

It should be noted that the animal studies used to evaluate the safety of N-Methyl-2-pyrazine were conducted using high concentrations of the substance, and the potential health effects of long-term exposure to lower concentrations of N-Methyl-2-pyrazine are not well understood.

Overall, the available data suggests that N-Methyl-2-pyrazine is generally safe when used in the recommended concentrations and under normal conditions of use.
However, it is important to follow safe handling procedures and to minimize exposure to the substance, particularly for workers who handle it in large quantities or for extended periods of time.
It is also important to follow the guidelines and regulations set by the regulatory agencies in your country or region.

In conclusion, N-Methyl-2-pyrazine is a floral fragrance ingredient and chemical intermediate that has been extensively studied for its safety.
The IFRA, EU and EPA have established safety guidelines and classifications for N-Methyl-2-pyrazine.
The available data suggests that N-Methyl-2-pyrazine is generally safe when used in recommended concentrations and under normal conditions of use.
However, it is important to follow safe handling procedures and to minimize exposure to the substance and to follow the guidelines and regulations set by the regulatory agencies in your country or region.