Recently, the paper "H 2 O 2 Self-Producing Single-Atom Nanozyme Hydrogels as Light-Controlled Oxidative Stress Amplifier for Enhanced Synergistic Therapy by Transforming "Cold" Tumors" by Li Guoxin and Zhu Daoming's team from the General Surgery Department of Nanfang Hospital was published as a research paper (Research Article ) was published online in Advanced Functional Materials , the top international journal of materials science
This achievement was funded by the Guangdong Provincial Key Laboratory of Accurate Minimally Invasive Diagnosis and Treatment of Gastrointestinal Tumors and other funds.
Zhu Daoming from General Surgery is the first author of the paper, and Nanfang Hospital is the first signing unit of the paper
Single-atom nanozymes (SAzymes) with peroxidase-like activity can change the cellular redox balance and show great application prospects in tumor therapy
However, the insufficient content of hydrogen peroxide inside solid tumors greatly limits the efficacy of single-atom nanozymes
In response to the above scientific problems, the research team co-encapsulated single-atom enzymes and camptothecin chemotherapeutics in injectable hydrogels to form a light-controlled oxidative stress amplification system
The system can enhance the effect of single-atom enzyme-catalyzed treatment, and at the same time, it is found that it can transform immunosuppressed "cold" tumors into "hot" tumors, has excellent synergistic anti-tumor immunotherapy ability, and has broad application prospects in the field of gastrointestinal tumor treatment and high clinical translatability
In recent years, under the leadership of Li Guoxin, the general surgery department of Nanfang Hospital has gradually developed into an "intelligent and precise minimally invasive surgery" with the construction concept of "innovative surgery, specialized surgery, and research-based surgery"
Relying on the Guangdong Provincial Key Laboratory of Accurate Minimally Invasive Diagnosis and Treatment of Gastrointestinal Tumors, the department has built an international, wide-crossing, and full-chain innovative ecology and an interdisciplinary and cross-industry R&D team.
Accurate and stable" is the ultimate goal of the research on individualized and precise diagnosis and treatment of tumors, in order to break through the bottleneck restricting the curative effect of gastrointestinal tumor surgery, and make substantial breakthroughs in the long-term survival of patients as soon as possible