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Recently, the paper "H 2 O 2 Self-Producing Single-Atom Nanozyme Hydrogels as Light-Controlled Oxidative Stress Amplifier for Enhanced Synergistic Therapy by Transforming "Cold" Tumors" by Li Guoxin and Zhu Daoming's team from the General Surgery Department of Nanfang Hospital was published as a research paper (Research Article ) was published online in Advanced Functional Materials , the top international journal of materials science
.
This achievement was funded by the Guangdong Provincial Key Laboratory of Accurate Minimally Invasive Diagnosis and Treatment of Gastrointestinal Tumors and other funds.
Single-atom nanozymes (SAzymes) with peroxidase-like activity can change the cellular redox balance and show great application prospects in tumor therapy
.
However, the insufficient content of hydrogen peroxide inside solid tumors greatly limits the efficacy of single-atom nanozymes
In recent years, under the leadership of Li Guoxin, the general surgery department of Nanfang Hospital has gradually developed into an "intelligent and precise minimally invasive surgery" with the construction concept of "innovative surgery, specialized surgery, and research-based surgery"
.
Relying on the Guangdong Provincial Key Laboratory of Accurate Minimally Invasive Diagnosis and Treatment of Gastrointestinal Tumors, the department has built an international, wide-crossing, and full-chain innovative ecology and an interdisciplinary and cross-industry R&D team.