The secret to the acceleration of new crown vaccine research and development

, Wang Xiangxi, a researcher at the Institute of Biophysics of the Chinese Academy of Sciences, published the results of the world's first animal experiment on the new coronavirus vaccine in the journal Science, and Wang Xiangxi, as one of the co-authors, under assumed scientific tasks such as vaccine purification program optimization, structural characteristic analysis and stability analysis, providing a preliminary basis and technical support for the successful implementation of the new coronavirus inactivated vaccine project.
in China's long-running battle against the new crown virus, Several of China's new crown vaccines have outsteed the world's attention. And the secret of acceleration can be seen from Wang Xiangxi's interest table.Chinese New Year's Eve, Wang Xiangxi has just returned to Beijing from an academic exchange on the African swine fever vaccine in the UK. He canceled his planned Spring Festival vacation to focus on the new coronary pneumonia vaccine.
" their own professional is viral structure, when the outbreak comes, if you do not do something within our power, it is not able to live their own professional, can not live in the country's training. He described his mood to the China Science Daily.
the theme of last year's Spring Festival overtime- African swine fever virus, the new coronavirus has too many unknowns, vaccine research and development can catch up with the outbreak? Do you want to do it? How do you do that? Who's going to do it? have been discussed over and over again.
Finally, Wang Xiangxi team and the Chinese Academy of Medical Sciences Institute of Medical Experimental Animals Qinchuan team, Zhejiang CDC Zhang Grim Team, Science and Technology Holdings Biotechnology Co., Ltd. and other scientific research teams and enterprises joined hands to join the team in vaccine development.
Under the outbreak, the streets are empty pedestrians are scarce, merchants are mostly closed doors and windows, Wang Xiangxi often set out early in the morning, in the "attention to protection" of the orders and family farewell, with the family prepared lunch and dinner to the laboratory, a work until three o'clock in the middle of the night.
from day to night, Wang Xiangxi team of experimenters are always ready, the virus strain samples immediately into the "battle", to carry out a variety of electro-mirror experiments and chemical and chemical analysis. "I just hope the vaccine comes out quickly, the article can be late, the vaccine is definitely not late." Wang Xiangxi said.not the first to start, but it was the first team in the new crown vaccine study to publish the results of animal trials.
" is to let the world know that we Chinese scientists are seriously developing vaccines, Chinese scientists are willing to work with scientists around the world to defeat the common enemy---- Wang Xiangxi said.
At present, Wang Xiangxi team involved in the development of this inactivated vaccine has been confirmed by animal experiments can quickly induce the production of specific neutral antibodies, the vaccine in non-human primate protection and safety has been initially tested. Phase I clinical studies of the vaccine have also been officially launched, and the first volunteers have successfully entered the group and completed the first injection.
He believes that it is the good foundation of cooperation between the units laid the acceleration of vaccine research and development, "whether enterprises or scientists, we are in the exhibition director, efficiently complete every link of vaccine development, the heart is only one idea is how to do a good job, make." "
" although the traditional thinking, but after time testing of inactivated vaccines more safe, our research and development idea is to prioritize the use of fast and safe vaccines to control the outbreak, and then gradually upgrade the new vaccine, the use of virus structure information to design a new genetically engineered vaccine, and ultimately to make the virus disappear on Earth. According to Wang Xiangxi, vaccine research and development has applied 11 strains of the virus from different countries to minimize interference caused by mutations in the virus.
materials supply, platform support,
biophysics support also ensures the speed of vaccine research and development, in order to cooperate with scientific research, the bioimaging center from the beginning of the third day of the operation. "As long as the application is made, the Institute will always support our needs to the best of its possible possible possible," Wang said."My sense of mission is not sudden, but a little bit gained." After
the School of Life Sciences at Sichuan University in 2009, Wang Xiangxi joined the Institute of Biophysics to conduct structural biology research.
and academicians served not only as his academic mentors, but also as his life mentors. "The leaders and senior scientists ted me on how to find my personal direction and how to be a good, missioned scientist."
At the beginning of the selection of professional, Wang Xiangxi did not think that his research work will be closely linked to the country's public health, but in the hands, feet and mouth virus, hepatitis A virus, encephalitis B virus, herpes virus, African swine fever virus research, the word "scientific mission" in his heart gradually has a specific connotation.
The interaction of each amino acid makes sense, the precise functioning of organisms is amazing, the nature of life is articulated at the molecular level, and structural biology allows researchers to see landscapes in which normal people are at all time but not.
are there in the structure of the virus particles? Which protein is more important for immune protection of the virus? As he works to answer these questions, the bridge between basic scientific research and the national economy and people's livelihood has been quietly built.
in the dark moment of the outbreak, Wang Xiangxi day and night adhere to the first line of scientific research.
"If I don't go, who's going to go?" At this time, it is more we engaged in infectious disease-related researchers to play a role, rather than in small outbreaks are very active, in the real big outbreak, but also worried about their infection and hide. "
" work requires the joint efforts of team members. As the head of the task force, if I don't come, if I don't work so hard, if I'm afraid of the outbreak myself, how can my staff overcome the difficulties?
to Wang Xiangxi, the honor of "the nation's upward good youth" is different from the other awards he has received - not only for the recognition of individual scientific research ability, but also for the recognition of personal social responsibility. "I feel honored that we are doing something that is meaningful to individuals, society, nations, and even humanity."
Although the domestic outbreak of new crown pneumonia has been initially controlled, but Wang Xiangxi has not yet felt relaxed, in addition to the stage victory, the intense work continues, he said: "Until the vaccine is officially put into use, will remain tense." "