The Shanghai Academy of Health Sciences found that insulin regulates the molecular mechanism of the liver's biological clock.

On August 31st Nature Communications, an international academic journal, published online a new research paper by Liuof the Institute of Nutritional Sciences of the Shanghai Institute of Life Sciences of the Chinese Academy of Sciences, in which insulin affects the molecular mechanisms of the liver's biological clock by regulating the biological clock core transcription factor Bmal1.
the circadian rhythm is a 24-hour, regulated rhythmic shock that is common in organisms.
mechanism that regulates the oneration of biological rhythms is called the circadian clock.
physiological activities of these organisms, such as sleep, insulin secretion, lipid production, liver sugar heterogeneity, etc., are regulated by the biological clock.
years, more and more research has found that the biological clock is very important to maintain the body's metabolic stability, biological clock disorder is one of the important factors that cause obesity, diabetes and other metabolic diseases.
At the molecular level, the biological clock consists mainly of two positive and negative feedback loops formed by positive regulatory factors Bmal1 and Clock, as well as negative feedback factors Cryptochrome (Cry1, Cry2), Period (Per1, Per2, Per3), and Rev-erb alpha.
Bmal1 and Clock are able to form heterogeneic binders that combine with E-box components in downstream gene initiator regions such as Cry, Per, and Rev-erb alpha to initiate the transcription of downstream genes.
Cry and Per are able to form heterogenetic complexes that enter the nucleus, inhibit the transcriptional activity of Bmal1 and Clock, thereby inhibiting their own expression and forming the first negative feedback loop;
Depending on where it exists, there are two types of biological clocks: a central biological clock, also known as the main biological clock, that exists in the upper nucleus of the heterocul cerebral vision, and an outer biological clock, which exists in outer tissues such as the liver and muscles.
light signals can be transmitted through the retina to the hemline, synchronousizing the central biological clock, allowing the body's physiological behavior to coordinate with the circadian rhythms produced by the Earth's transition.
other factors, such as temperature, diet, etc., are regulated by the central biological clock.
recent studies have found that changing diet resets the outer biological clock with little effect on the central biological clock.
this suggests that the regulation of the outer biological clock by diet is independent of the regulation of the central biological clock, and that the regulation of the outer biological clock by diet is greater than that of the central biological clock.
although the relationship between diet and the outer biological clock, especially the liver biological clock, has been a hot topic in recent years, its molecular mechanism is still unclear.
Under the guidance of Liu , Ph.D. students Party Fabin, Sun Xiujie, etc. have found that in the feeding state, insulin secreted by the pancreas can pass the signal to the cell through the insulin subject on the surface of the liver cell, activating the PI3K-AKT2 signal. Path, the activated AKT2 is capable of phosphorylation Bmal1-Ser42, and the phosphorylated Bmal1 binds to 14-3-3, which in turn stabilizes Bmal1 in the cytotyte, thereby inhibiting the expression of the lower Bmal1/Clock gene.
changing the normal dietary rhythms of mice through food traction tests found that, on the one hand, the rhythms secreted by insulin change, causing bmal1 to change the pattern of aggregation in the nucleation of the cell, Dbp, The expression phase of downstream rhythm genes such as Rev-erb alpha was reversed, indicating that the rhythm of the liver's biological clock was reset;
these findings not only reveal the molecular mechanisms that regulate the occurrence of the liver's biological clock as an important feeding signal, but also provide new revelations about the relationship between irregular diet and biological clock disorders, and the occurrence of metabolic syndrome.
.