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The dynamic changes of mitochondria and metabolic reprogramming play a key regulatory role in the fate determination of CD8+ T cells
Cheng Jinke’s research group at Shanghai Jiaotong University School of Medicine recently published a research paper entitled Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development in Nature Communications.
In terms of molecular mechanism, a new mechanism was discovered that SENP1-Sirt3 axis regulates OPA1 shearing and promotes mitochondrial inner membrane fusion
This study reveals the molecular mechanism of the immune microenvironment through regulating T cell mitochondrial metabolism, affecting the formation of memory T cells and the ability of anti-tumor
Dr.