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Fat is the main form of energy storage in organisms, and fat energy metabolism is closely related to many major human diseases (obesity, diabetes, cancer, etc.).
the fat in the cells is stored mainly in lipid droplets.
and dynamic regulation of lipid droplets are closely related to cell function and metabolic state.
previous studies have found many molecular mechanisms that affect the dynamic changes of lipid storage and lipid droplets in different model systems, but the understanding of lipid storage and fat droplet dynamic regulation is still not thorough enough.
work of the Huang Xun Research Group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences found that phospholipid ACID PA, lipid drop surface PAT family protein and lipase mutually regulate lipid drop size (PLoS Genetics 2011, J Cell Science 2012 ), cytosine dilipid glycelin synthase (Cds) coordinates cell lipid storage and growth (PLoS Genetics 2014), and calcium-stabilized regulated lipid storage in cells (Cell Metabolism 2014).
work by the Huangxun Research Group found that TRF2 and TF9, members of the General Transcription Factor, were able to specifically regulate the size of lipid droplets in fat cells and the composition of fatty acids in phospholipids.
trf2 and taff9 gene invigoration causes lipid droplets in fat cells to increase, and knocking down trf2 and taff9 also causes increased levels of long-chain fatty acids in a variety of phospholipids.
further analysis showed that the effects of TRF2 and TF9 on the above-mentioned processes were achieved by regulating the transcription of a specific set of genes of interest, including the peroxidase fatty acid beta oxidation-related genes and other genes such as eIF2B-d.
basic transcription factors are generally considered to be commonly needed for all transcriptions, the study reveals the special role of basic transcription factors in lipid metabolic regulation.
the findings were published in PLoS Genetics.
, Ph.D. student of Huangxun Research Group, was the first author of the paper, and Wang Yong, Research Group of the Institute of Genetic Development of the Chinese Academy of Sciences, and Wang Yong Of the Institute of Mathematics and Systems Science of the Chinese Academy of Sciences participated in the collaboration.
the study was supported by the Leading Special Project of the Chinese Academy of Sciences, the Ministry of Science and Technology and the National Natural Science Foundation of China.
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