The spread of pan-resistant genes in the poultry industry chain and poultry breeding environment.

The drug resistance research team, led by Shen Jianzhong, a member of the Chinese Academy of Engineering and dean of the School of Animal Medicine at the Agricultural University of China, published a paper in Nature-Microbiology on February 6th, revealing for the first time the spread of the pan-resistant genes blackM and mcr-1 in the poultry industry chain and poultry farming environment.
the study could provide new insights into how drug-resistant genes enter and contaminate the human food supply chain, or help develop new strategies to reduce their emergence and further spread in agriculture.
carbon penicillin antibiotics are the most important antimicrobial drugs for the clinical treatment of multi-drug-resistant Glollaton-negative bacterial infections, while peptides are the last line of defense against these bacterial infections.
, two drug-resistant genes that can fight these antibiotics, blaNDM and mcr-1, have been identified in contaminated bacteria in the human food supply chain, but it is unclear how they enter and spread.
In order to find out the prevalence and spread characteristics of these two types of pan-resistant genes in China's poultry industry chain and its breeding environment, the research team monitored and analyzed the resistance of more than 1000 samples collected in the domestic chicken production chain, and found that E. coli can carry the drug-resistant gene mcr-1 from upstream chicken farms along the chicken production chain all the way to the supermarket, indicating that the sticky As an antibacterial growth agent in the poultry industry, a large number of widespread and widespread use, may be the main reason for the widespread presence of the drug-resistant gene, and the drug-resistant gene blandM, although negative in upstream chicken farms, but in commercial chicken farms in chickens, birds, dogs, flies and even breeders carrying E. coli positive rate is very high, and can spread downstream of the production chain. Wang Yang, the first author of the
paper and a professor at the School of Animal Medicine of The Agricultural University of China, points out that isolated carbon penicillin-resistant E. coli is closely related to the clinically isolated Blind M drug-resistant E. coli in Australia, the United States, China and other countries.
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