The study found a new mechanism for coronary heart disease caused by mitochondrial gene mutation

professor Guan Minxin of Zhejiang University's Institute of Genetics found that a mutation in mitochondrial genes causes damage to the endotkin of blood vessels, which in turn induces coronary heart disease. The paper was recently published online in the internationally renowned journal Nucleic Acid Research.
mitochondrials are a type of organel commonly used in human cells and are 'power plants' that provide energy for cells to maintain function and metabolism. Mitochondrials carry 37 genes inherited from their mothers, and mutations are one of the risk factors for coronary heart disease. Professor Guan Minxin said coronary heart disease, short for coronary atherosclerotic heart disease, is a common complex disease caused by genetic factors, environmental factors or the interaction between the two. Globally, coronary heart disease is becoming a threat to human life and health, and its morbidity and mortality rate have been on the rise in recent years.
in 2011, the team discovered and locked out mitochondrial mutations in a large-scale screening of mitochondrial gene mutations in patients with cardiovascular disease in Beijing. In the latest study, the Guan Minxin team revealed in depth how mitochondrial gene mutations at a particular location eventually led to coronary heart disease. The researchers likened it to a faulty doll-grabbing machine.
" mitochondrials are transported RNA (tRNA), which, like a doll-grabbing machine, grabs and transports amino acids to synthesize proteins. After the gene mutation, the transport ICC structure as the doll's 'gripper' will be affected, which is reflected in the direct reduction of the number of transport ICTs, but also the 'secondary', disrupting protein synthesis, so that mitochondrial function is impaired. Guan Minxin said.
dysfunction of mitochondrials will lead to insufficient cellular energy supply, increase free-forming, reduce the migration capacity of endosthyl cells and angiogenesic capacity, and eventually lead to the damage of endothyl cells in blood vessels. Vascular endotrical damage is one of the root causes of coronary atherosclerosis.
said that the study of coronary heart disease caused by mitochondrial dysfunction is a new perspective on the pathogenicity of the study, and also provides a new potential target for the treatment of coronary heart disease. (Source: Xinhua News Agency, Zhu Han)