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    Home > Medical News > Medical Science News > The study found that Alzheimer's disease is a contributing factor

    The study found that Alzheimer's disease is a contributing factor

    • Last Update: 2020-12-19
    • Source: Internet
    • Author: User
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    U.S. researchers report in a new issue of the British journal
    that meninges lymphatic dysfunction may be a key factor in the increase in Alzheimer's disease and age-related cognitive impairment. The discovery promises to provide new ideas for treating related diseases.
    have believed that the brain lacks a lymphatic system. But in 2014, U.S. researchers discovered the presence of meninges. The researchers found meninges and lymphatic tubes in rodents, non-human primates and humans, but their function in the central nervous system and their role in diseases of the central nervous system are unclear.
    In the new study, researchers at the University of Virginia School of Medicine and Virginia Tech, who found the meninges, confirmed that the meninges lymphatic tubes can draw large molecules from the central nervous system cerebrospinal fluid and inter-brain tissue fluid to the neck lymph nodes.
    study found that impaired meninges and lymphatic tube function in adult mice led to decreased learning and memory, and that age-related cognitive impairment in older mice was associated with severe damage to meninges' lymphatic tube function. After the elderly mice were treated with vascular endospinal growth factors, the meninges' lymphatic tubes improved their ability to remove large molecules from cerebrospinal fluid and inter-brain tissue fluid, and their learning and memory ability improved accordingly.
    Monson, an assistant professor of biomedical engineering at Virginia Tech and one of the co-authors of the study, says fluid flow in the brain slows down during aging, sometimes at half the rate of a young age. The meninges lymphatic tubes excrete the protein that causes Alzheimer's disease along with other cell waste, and a slower flow rate causes the protein to accumulate. Existing studies suggest that Alzheimer's disease is associated with excessive accumulation of beta amyloid protein in the brain.
    researchers have developed a hydrogel that contains molecules that dilate the meninges' lymphatic tubes, which can spread through the brain and enter the meninges' lymphatic tubes. Researchers believe similar hydrogels could become a non-invasive drug for Alzheimer's disease and age-related cognitive impairment in the future. (Source: Xinhua News Agency Zhou Zhou)
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