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    Home > Active Ingredient News > Drugs Articles > The study found that green tea extract may help eliminate antibiotic resistant bacteria

    The study found that green tea extract may help eliminate antibiotic resistant bacteria

    • Last Update: 2019-10-08
    • Source: Internet
    • Author: User
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    Recently, scientists from the University of Surrey and other institutions have found that a natural antioxidant in green tea may help eliminate antibiotic resistant bacteria The compound, called epigallocatechin (EGCG), restores the activity of the antibiotic aztreonam, a commonly used antibiotic for the treatment of Pseudomonas aeruginosa infection Relevant research was published in the International Journal of medical microbiology In order to evaluate the synergistic therapeutic effect of EGCG and aztreonam, the researchers conducted in vitro experiments (http:// to analyze the mechanism of interaction between EGCG and aztreonam The researchers found that the combination of EGCG and aztreonam can effectively reduce the number and level of Pseudomonas aeruginosa compared with single treatment In vivo experiments with Galleria mellonella (http:// the researchers also observed the synergistic effect of EGCG and aztreonam Compared with single treatment, the combination of EGCG and aztreonam can significantly improve the survival rate of cercaria mellonella infected with bacteria In Pseudomonas aeruginosa, EGCG can increase bacterial uptake of aztreonam by increasing bacterial permeability, while another potential mechanism is that EGCG can interfere with biochemical pathways related to antibiotic susceptibility in bacterial cells, the researchers said  
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