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    Home > Medical News > Latest Medical News > The study found that middle-aged people suffer from H1N1 influenza virus

    The study found that middle-aged people suffer from H1N1 influenza virus

    • Last Update: 2014-11-13
    • Source: Internet
    • Author: User
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    Researchers at the Wistar Institute in the United States have found out why middle-aged people suffered from the H1N1 virus during the 2013-2014 flu season According to research published in proceedings of the National Academy of Sciences by Dr Scott Hensley and others, a new mutation of H1N1 virus may cause more diseases in middle-aged people, and the community may need to change the strategy of selecting virus strains for vaccine Vaccines stimulate the immune system to produce antibody proteins that fight against substances called antigens Bacteria and viruses, for example, are the sources of infection that produce antigens Cells that produce effective antibodies are preserved by the immune system, ready to resist another infection of the same or similar origin Despite the vaccine, 36000 people die each year in the United States alone, while 500000 people around the world are not Generally speaking, children's and old people's immune systems are more vulnerable to influenza virus because of their vulnerability However, between 2013 and 2014, doctors found that a particularly large number of middle-aged people were affected by H1N1 Monitoring agencies have found several new mutations in hemagglutinin (HA) glycoprotein, and they have also used standard serum tests to prove that these mutations do not change the antigenic characteristics of the virus However, Dr Hensley and others found that just one of the mutations in the HA region allowed the virus to avoid immune responses in some middle-aged people When we are first infected with influenza virus, the immune system will leave a "mark" According to the data, the flu in the 1870s-80s "imprinted" on the immune system of these middle-aged people, affecting their current response to the H1N1 vaccine The team found that 42% of people born between 1965 and 1979 had antibodies that could recognize these mutated ha regions The researchers noted that the main changes in influenza virus antigens were determined in the surveillance community by using the antiserum of ferrets who recovered from the mainstream influenza virus infection Therefore, it is suggested that future influenza vaccines should include these viral antigens that can target this region Dr Hensley suggested that we should reevaluate the way we monitor influenza viruses with different antigenic characteristics, as well as the means to select vaccine strains Original search: S L Linderman, B S chambers, S J zost, K Parkhouse, Y Li, C Herrmann, A H ellebody, D M Carter, S F Andrews, N - Y Zheng, M Huang, Y Huang, D Strauss, B H Shaz, R L odinka, G Reyes Teran, T M Ross, P C Wilson, R Ahmed, J D bloom, S E Hensley  Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1409171111
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